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IFI27 — IL7
Text-mined interactions from Literome
Barata et al., J Exp Med 2004
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
PI3K activation was mandatory for
IL-7 mediated Bcl-2 up-regulation,
p27kip1 down-regulation, Rb hyperphosphorylation, and consequent viability and cell cycle progression of T-ALL cells
Nakayama et al., Blood 2009
(Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) :
Inhibition of
IL-7R signaling or JAK3/STAT5 activity
resulted in the induction of
p27 ( kip1 ) expression and cell-cycle arrest, accompanied by apoptosis in the leukemia cells