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LEP — PI3

Text-mined interactions from Literome

Szanto et al., Proc Natl Acad Sci U S A 2000 : In Fao cells, leptin alone had no effects on the insulin signaling pathway, but leptin pretreatment transiently enhanced insulin induced tyrosine phosphorylation and PI 3-kinase binding to IRS-1, while producing an inhibition of tyrosine phosphorylation and PI 3-kinase binding to IRS-2
Sweeney et al., Endocrinology 2000 : Moreover, leptin stimulated phosphotyrosine associated PI 3-kinase activity in these cells
Oda et al., Kobe J Med Sci 2001 : Leptin stimulated phosphorylation and activation of mitogen activated protein ( MAP ) kinases, and also increased phosphatidylinositol (PI) 3-kinase activity
Huang et al., J Biol Chem 2004 (Insulin Resistance...) : Contrary to the effects of leptin in lean livers, leptin did not activate PI 3-kinase in livers from DIO rats ... defective leptin activation of PI 3-kinase as a novel mechanism of leptin resistance
Mirshamsi et al., BMC neuroscience 2004 : Leptin stimulated PI3-kinase activity in GT1-7 cells and an increase in PtdIns ( 3,4,5 ) P3 could be detected, which was prevented by PI3K inhibitors
Carvalheira et al., Obes Res 2005 : Insulin alone is able to produce molecular activation of insulin receptor substrates (IRSs)/phosphatidylinositol 3-kinase ( PI 3-kinase ) /Akt and mitogen activated protein ( MAP ) kinase signaling pathways in hypothalamus, whereas leptin alone activates MAP kinase and IRSs/PI 3-kinase signaling with no effect on Akt
Lee et al., Int J Obes Relat Metab Disord 2005 (Hyperplasia...) : We also confirm that leptin activates both PI 3-kinase and ERK1/2 in these cells
Belgardt et al., Cell Metab 2008 (Body Weight...) : Insulin- and leptin stimulated phosphatidylinositol-3 kinase (PI3K) activation has been demonstrated to play a critical role in central control of energy homeostasis
Zeigerer et al., Exp Cell Res 2008 : Stimulation with insulin for 15 min induced the same level of leptin release and was blocked by Brefeldin A. Inhibiting PI 3-kinase with wortmannin had no effect on insulin stimulation of leptin secretion
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF, IL-1/IL-1R tI
Rahmouni et al., Diabetes 2009 (Body Weight) : The pharmacological antagonists of ERK1/2 did not attenuate leptin induced activation of STAT3 or PI 3-kinase
Berti et al., Diabetologia 1997 (Obesity) : Leptin did not stimulate PI3-kinase activity in IRS-1 immunoprecipitates ; however, PI3-kinase activation could be demonstrated in p85 alpha immunoprecipitates ( 3.04 +/- 1.5 fold of basal )
Kellerer et al., Diabetologia 1997 : While insulin stimulated PI-3 kinase activity is detected in IRS-1 and IRS-2 immunoprecipitates, leptin stimulated PI-3 kinase activity is found only in IRS-2 immunoprecipitates, suggesting that the leptin signal to PI-3 kinase occurs via IRS-2 and not IRS-1