Gene interactions and pathways from curated databases and text-mining

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IL6 — IL6ST

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Bhat et al., Biochem Biophys Res Commun 1999 : alpha-thrombin inhibits interleukin-6 induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts ... These results demonstrate, for the first time, that in HLF cells alpha-thrombin inhibits IL-6 induced Stat3 signaling via activation of MAPKK1 and that this cross-talk regulates IL-6 induced gp130 gene expression
Sui et al., Blood 1999 : Together with the presence of functional sIL-6R in human serum and relative unresponsiveness of human Mk progenitors to IL-6 in vitro, current results suggest that the role of IL-6 may be mainly mediated by sIL-6R, and that the gp130 signaling initiated by the sIL-6R/ IL-6 complex is involved in human megakaryopoiesis in vivo
Gaillard et al., Eur Cytokine Netw 1999 (Paraproteinemias) : Soluble gp130 had already been shown to inhibit IL-6 signaling by inactivating the IL-6/IL-6R complex
Haggiag et al., FEBS Lett 1999 : Activation of gp130 signaling by IL6RIL6 appears comparable to cyclic AMP elevating agents to induce the myelin gene products in DRG and in pure Schwann cell cultures
Xie et al., Leuk Res 1999 : Furthermore, activation of the PMA induced gp130 receptor by exogenous IL-6 potentiated the differentiating effects of PMA
Xie et al., Cancer Lett 2000 (Leukemia, Promyelocytic, Acute) : Furthermore, activation of the RA-induced gp130 by exogenous IL-6 potentiated the differentiating effects of RA
Müllberg et al., J Immunol 2000 (Sarcoma, Kaposi) : IL-6 receptor independent stimulation of human gp130 by viral IL-6
Pflanz et al., J Immunol 2000 : On the basis of our data, a model for the mechanism of IL-6 induced gp130 activation is proposed
Matsui et al., Int J Hematol 2000 : We have reported that simultaneous activation of glycoprotein (gp) 130 and c-kit signals by interleukin (IL)-6 , soluble IL-6 receptor ( sIL-6R ), and stem cell factor (SCF) promotes proliferation of human hematopoietic progenitor cells and their differentiation into erythroid, myelocytic, and megakaryocytic cells
Gunaje et al., Mol Cell Biol Res Commun 2000 (MAP Kinase Signaling System) : We demonstrate that exposure of CCL39 cells to TGF-beta completely inhibits IL-6 induced Stat3 tyrosine phosphorylation and gp130 gene expression
Shuto et al., Neuroreport 2001 : In contrast, IL-6 enhanced the mRNA expression of gp130 and CNTF
Schaeffer et al., Mol Cell Biol 2001 : Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor beta-chain, gp130
Ling et al., Crit Care Med 2002 : In endotoxin treated rats, there was significant inhibition of interleukin-6 activation of janus kinase-1, gp 130 , the interleukin-6 receptor, STAT1, and STAT3
Naka et al., Arthritis Res 2002 (Arthritis, Rheumatoid...) : IL-6 signaling is mediated exclusively by the common signal transducing component gp130 , which is also essential for signal transduction of other cytokines of the leukemia inhibitory factor (LIF)/IL-6 family
Tebbutt et al., Nat Med 2002 (Adenoma...) : In contrast, mice harboring the reciprocal mutation ablating STAT1/3 signaling ( gp130 ( Delta STAT ) ), or deficient in IL-6 mediated gp130 signaling ( IL-6 ( -/- ) mice ), showed impaired colonic mucosal wound healing
Kishimoto et al., J Autoimmun 1992 (Arthritis, Rheumatoid) : Binding of IL-6 to IL-6R triggers the association of IL-6R and gp130 , and gp130 in turn transduces the signal
Leu et al., Oncogene 2003 (Esophageal Neoplasms) : IL-6 stimulation induced a rapid phosphorylation of gp130 and STAT3, and a dominant negative STAT3 completely abolished the antiapoptotic effect
Kovacs et al., Biomed Pharmacother 2003 (Multiple Myeloma) : How does interleukin-6 affect the membrane expressions of interleukin-6 receptor and gp130 and the proliferation of the human myeloma cell line OPM-2 ? ... This is the first report that IL-6 inhibits the membrane expression of gp130 , although the proliferation of the myeloma cells increases
Omori et al., J Biol Chem 2004 : Consistent with the expression of its mRNA, the HG condition also increased the expression of gp130 protein, and phosphorylation of the tyrosine residue by gp130 was enhanced significantly by IL-6/sIL-6R stimulation
Zhou et al., Int J Hematol 2004 (Multiple Myeloma) : In CD45+ U266 cells, IL-6 increased tyrosine phosphorylation of gp130 and STAT3 and stimulated the level of Mcl-1 protein expression
Wang et al., J Invest Dermatol 2004 : Application of the fusion protein gp130-FC , a specific inhibitor of the agonist IL-6/sIL-6 receptor complex, delayed barrier repair in wild, but not in IL-6-deficient mice
Zancai et al., Int J Oncol 2004 : These changes, however, were not related to the enhanced production of endogenous IL-6 induced by RA in LCLs. RA-induced modulation of IL-6 receptor components did not abolish IL-6 mediated phosphorylation of gp130 , whereas JAK1 and STAT3 phosphorylation and activation induced by IL-6 were markedly inhibited
Saito et al., J Immunol 1992 : Both gp130 and IL-6R mRNA in liver were up-regulated in vivo by IL-6
Nishimichi et al., Dev Comp Immunol 2006 : IL-6 signaling is regulated by two receptors, a specific alpha chain ( IL-6Ralpha ) and a signal transducer, gp130
Kishimoto et al., Int J Immunopharmacol 1992 : Binding of IL-6 to IL-6R triggers the association of IL-6R and gp130 , and gp130 in turn transduces the signal ... NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6 triggered association of IL-6R and gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre existing NF-IL6 protein, leads to binding of NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes
Robb et al., Proc Natl Acad Sci U S A 2005 (Inflammation) : Mice lacking SOCS3 die at midgestation because of placental failure, and SOCS3 ablation in a cell-type-specific manner results in changes in the functional outcome of gp130 signaling in response to IL-6
Mitsuyama et al., Gut 2006 (Disease Models, Animal...) : We also examined the effects of intravenously injected hyper-IL-6, an IL-6/soluble IL-6 receptor fusion protein, and of soluble gp130-Fc , a specific inhibitor of soluble IL-6 receptor signalling, on STAT3 phosphorylation and disease severity in SAMP1/Yit mice
Kovacs et al., TheScientificWorldJournal 2006 (Lymphoma, B-Cell...) : In this study, we investigated the effects of IL-6 , IL-6 receptor antagonist (IL-6RA), and gp130 antagonist (gp130A) on the membrane expressions of IL-6R and gp130 , on the viability, on the proliferation, on the DNA synthesis, and on the cell cycle phases in several multiple myeloma ( MM ) cell lines and B cell lymphoma cell lines
Cronstein et al., Bull NYU Hosp Jt Dis 2007 (Arthritis, Rheumatoid) : Il-6 signaling involves both a specific IL-6 receptor (IL-6R) and a ubiquitous signal transducing protein, gp130 that is also utilized by other members of the IL-6 family
Tanaka et al., Mol Cell Biol 2008 : Here we found that IL-6 stimulation induced lysosome dependent degradation of gp130 , which correlated with an increase in the K63 linked polyubiquitination of gp130 ... We also found that IL-6 induced a rapid translocation of gp130 from the cell surface to endosomal compartments
Kulikov et al., Genes, brain, and behavior 2010 (Catalepsy) : Glycoprotein gp130 is involved in the interleukin-6 (IL-6) and related cytokines ' signaling
Kobayashi et al., Mol Biotechnol 2011 : ELISAs revealed that RA07 could not inhibit IL-6 from binding to the IL-6 receptor (IL-6R), but could inhibit the IL-6/IL-6 complex binding to gp130
Lee et al., J Immunol 2011 (Fetal Membranes, Premature Rupture...) : Soluble gp130 ( sgp130 ) selectively inhibits IL-6 trans signaling
Burton et al., Journal of neuroinflammation 2011 : Soluble gp130 attenuated IL-6- and LPS stimulated IL-6 receptor (IL-6R) activation along with IL-6 protein release in both microglial ( BV.2 ) and neuronal ( Neuro.2A ) cell types in vitro
Silver et al., J Immunol 2011 (Genetic Predisposition to Disease...) : Collectively, these studies highlight that a failure to abbreviate IL-6 mediated gp130 signaling results in a profound anti-inflammatory signal that blocks the generation of protective immunity to T. gondii
Garbers et al., J Biol Chem 2011 : Soluble gp130 ( sgp130 ) specifically inhibits IL-6 trans signaling but was described to not interfere with classic signaling via the membrane bound IL-6R
Taga et al., Cell 1989 : In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with gp130 in the presence of IL-6 and mediate its function
De Serio et al., J Mol Biol 1995 : While IL-6 induces gp130 dimerization, CNTF, after the initial interaction with the specific, non signalling receptor subunit, CNTFR, induces the formation of gp130/LIF-receptor heterodimers
Matsuda et al., Blood 1995 : In this study we show that in addition to Jak family tyrosine kinase, the stimulation of gp130 by IL-6 plus soluble IL-6 receptor alpha induced the activation of Btk and Tec tyrosine kinases, whereas IL-3 and granulocyte colony stimulating factor activated Tec but not Btk in a pro-B cell line
Wang et al., Gene 1995 (Acute-Phase Reaction) : Metabolic labeling, using [ 32P ] orthophosphate or anti-phosphotyrosine antibody ( Ab ) blot experiments revealed that both IL-6 and CNTF induced tyrosine phosphorylation of gp130 , and the Jak1 and Jak2 kinases in a dose- and time dependent manner
Saito et al., J Immunol Methods 1993 : Some of the mAbs inhibited the IL-6 induced association of soluble gp130 and soluble IL-6 receptor
Schwabe et al., J Clin Invest 1994 (Multiple Myeloma) : Second, IFN-alpha induced IL-6 predominantly down-regulated membrane bound gp130
Murakami et al., Science 1993 : IL-6 induced homodimerization of gp130 and associated activation of a tyrosine kinase ... The IL-6 induced gp130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor (LIF) receptor ( LIFR ) and gp130 in response to the LIF or ciliary neurotrophic factor (CNTF)
Kang et al., Cell Immunol 1996 (Multiple Myeloma) : Interestingly, the presence of okadaic acid induced the up-regulation of IL-6 receptor expression as well as the down-regulation of IL-6 induced gp130 phosphorylation in the myeloma cells
Ikeda et al., Brain Res 1996 (Disease Progression...) : IL-6 triggers homodimerization of gp130 , whereas CNTF and LIF induce heterodimerization of gp130 and LIF receptor
Berger et al., Blood 1997 (Multiple Myeloma) : IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal transducing subunit gp130 , the gp130 associated protein tyrosine kinases Jak1, Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen activated protein kinase Erk2, and accumulation of GTP bound p21ras ... Prior treatment of U266 cells with IFN-beta downregulated IL-6 induced tyrosine phosphorylation of gp130 , Jak2, PTP1D/Syp, Shc, and Erk2, and GTP loading of p21ras
Simpson et al., Protein Sci 1997 (Arthritis, Rheumatoid...) : Like the other members of this family, IL-6 induces growth or differentiation via a receptor-system that involves a specific receptor and the use of a shared signaling subunit, gp130
Ogata et al., J Immunol 1997 (Multiple Myeloma) : IL-6 induced phosphorylation of JAK kinases and gp130 , regardless of the proliferative response of MM cells to this growth factor
März et al., Eur J Neurosci 1997 : Interleukin-6 (IL-6) on target cells binds to the specific IL-6 receptor (IL-6R) and subsequently induces homodimerization of the signal transducing protein gp130
Dahmen et al., Biochem J 1998 : Taken together, our data support the concept that IL-6 and IL-11 activate gp130 by very similar molecular mechanisms
Hammacher et al., J Biol Chem 1998 : The data suggest that gp130-activation by IL-6 and LIF requires different regions of gp130, that the Ig-like module of gp130 may be required for IL-6 induced gp130 dimerization, and that the stoichiometry of the high affinity IL-6 receptor-complex differs from those of the receptor-complexes for LIF and OSM