◀ Back to IL6
IL6 — IL6ST
Pathways - manually collected, often from reviews:
-
KEGG Cytokine-cytokine receptor interaction:
IL6
→
Complex of IL6R-IL6ST
(protein-protein, activation)
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SOCS3 (SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
SOCS3 (SOCS3)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, collaborate)
Schmitz et al., J Biol Chem 2000
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
MITF (MITF)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/PIAS3 complex (STAT3-PIAS3)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
PIAS3/MITF complex (PIAS3-MITF)
(modification, activates)
Sonnenblick et al., Mol Cell Biol 2004, Chung et al., Science 1997
Evidence: mutant phenotype, reporter gene, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
PTPEC (PTPRE)
→
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4)
(modification, inhibits)
Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA complex (IL6-IL6R)
→
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4)
(modification, collaborate)
Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA complex (IL6-IL6R)
→
gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4)
(modification, collaborate)
Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 complex (IL6-IL6R-IL6ST-TYK2-LMO4)
→
gp130 (dimer)/TYK2/TYK2/LMO4 complex (TYK2-IL6ST-LMO4)
(modification, collaborate)
Tanuma et al., J Biol Chem 2000, Boulanger et al., Science 2003, Hibi et al., Cell 1990, Taga et al., Cell 1989, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
GRB2/SOS1/GAB family complex (GRB2-SOS1-GAB1_GAB2)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
SHP2 (PTPN11)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Kim et al., Mol Cell Biol 1999, Podar et al., J Biol Chem 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1 (STAT1)
(modification, activates)
Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer ) complex (STAT3)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
FOXO1 (FOXO1)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1)
(modification, activates)
Kortylewski et al., J Biol Chem 2003
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 complex (IL6-IL6R-IL6ST-JAK2-LMO4)
→
IL6/IL6RA complex (IL6-IL6R)
(modification, collaborate)
Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Hibi et al., Cell 1990, Taga et al., Cell 1989, Narazaki et al., Proc Natl Acad Sci U S A 1994, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 complex (IL6-IL6R-IL6ST-JAK2-LMO4)
→
gp130 (dimer)/JAK2/JAK2/LMO4 complex (JAK2-IL6ST-LMO4)
(modification, collaborate)
Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Hibi et al., Cell 1990, Taga et al., Cell 1989, Narazaki et al., Proc Natl Acad Sci U S A 1994, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA complex (IL6-IL6R)
→
gp130 (dimer)/JAK2/JAK2/LMO4 complex (JAK2-IL6ST-LMO4)
(modification, collaborate)
Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Hibi et al., Cell 1990, Taga et al., Cell 1989, Narazaki et al., Proc Natl Acad Sci U S A 1994, Lütticken et al., Science 1994, Stahl et al., Science 1994
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
PIAS1 (PIAS1)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1 (STAT1)
(modification, activates)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT1/PIAS1 complex (STAT1-PIAS1)
(modification, activates)
Liu et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
MKK6 (MAP2K6)
(modification, activates)
Bode et al., Biol Chem 2001
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
VAV1 (VAV1)
(modification, activates)
Schuringa et al., Biochem J 2000
-
NCI Pathway Database SHP2 signaling:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
SHP2 (PTPN11)
(modification, activates)
Schaper et al., Biochem J 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4)
→
IL6/IL6RA complex (IL6-IL6R)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
gp130 (dimer)/JAK1/JAK1/LMO4 complex (JAK1-IL6ST-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
PTPEC (PTPRE)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, inhibits)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA complex (IL6-IL6R)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
(modification, collaborate)
Kurth et al., J Immunol 2000, Tanuma et al., J Biol Chem 2000, Pflanz et al., J Immunol 2000, Chow et al., Science 2001, Haan et al., J Biol Chem 2001, Boulanger et al., Science 2003, Novotny-Diermayr et al., J Biol Chem 2005, Schroers et al., Protein Sci 2005, Giese et al., J Cell Sci 2005, Murakami et al., Proc Natl Acad Sci U S A 1991, Tenhumberg et al., Biochem Biophys Res Commun 2006, Hibi et al., Cell 1990, Taga et al., Cell 1989, Guschin et al., EMBO J 1995, Horsten et al., FEBS Lett 1995, Ward et al., J Biol Chem 1994, Lütticken et al., Science 1994, Yawata et al., EMBO J 1993, Murakami et al., Science 1993, Horsten et al., J Biol Chem 1997, Rodig et al., Cell 1998, Kurth et al., J Immunol 1999
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
Hck (HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
Hck (HCK)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/Hck complex (IL6-IL6R-IL6ST-JAK1-LMO4-HCK)
(modification, collaborate)
Schaeffer et al., Mol Cell Biol 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
STAT3 (STAT3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
nPKC-delta (PRKCD)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL6-mediated signaling events:
nPKC-delta (PRKCD)
→
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3)
(modification, activates)
Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, physical interaction, other species
-
Reactome Reaction:
IL6
→
IL6ST
(reaction)
Jostock et al., Eur J Biochem 2001*, Hemmann et al., J Biol Chem 1996, Schaper et al., Biochem J 1998
-
Reactome Reaction:
IL6ST
→
IL6
(reaction)
Hibi et al., Cell 1990, Taga et al., Cell 1989
-
Reactome Reaction:
IL6
→
IL6ST
(indirect_complex)
Jostock et al., Eur J Biochem 2001*
-
Reactome Reaction:
IL6ST
→
IL6
(indirect_complex)
Hibi et al., Cell 1990, Taga et al., Cell 1989
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
IL6
—
IL6ST
Boulanger et al., Science 2003
-
IRef Bind Interaction:
Complex of IL6ST-IL6R-IL6ST-IL6R-IL6-IL6
Skiniotis et al., Nature structural & molecular biology 2005*
-
IRef Bind_translation Interaction:
IL6
—
IL6ST
(x-ray crystallography)
Boulanger et al., Science 2003
-
IRef Dip Interaction:
IL6ST
—
IL6
(direct interaction, x-ray crystallography)
Chow et al., Science 2001
-
IRef Dip Interaction:
IL6ST
—
IL6
(direct interaction, biophysical)
Paonessa et al., EMBO J 1995*
-
IRef Hprd Interaction:
IL6
—
IL6ST
(in vivo)
Schwantner et al., J Biol Chem 2004*
-
IRef Hprd Interaction:
Complex of IL6R-IL6ST-IL6R-IL6-IL6ST-IL6-IL6ST-IL6R-IL6
(in vivo)
Li et al., J Virol 2001*, Boulanger et al., Science 2003
-
IRef Intact Interaction:
Complex of 13 proteins
(physical association, x-ray crystallography)
Boulanger et al., Science 2003
-
IRef Ophid Interaction:
IL6ST
—
IL6
(aggregation, confirmational text mining)
Schwantner et al., J Biol Chem 2004*
-
IRef Ophid Interaction:
IL6ST
—
IL6
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Bhat et al., Biochem Biophys Res Commun 1999
:
alpha-thrombin inhibits
interleukin-6 induced Stat3 signaling and
gp130 gene expression in primary cultures of human lung fibroblasts ... These results demonstrate, for the first time, that in HLF cells alpha-thrombin inhibits IL-6 induced Stat3 signaling via activation of MAPKK1 and that this cross-talk regulates
IL-6 induced
gp130 gene expression
Sui et al., Blood 1999
:
Together with the presence of functional sIL-6R in human serum and relative unresponsiveness of human Mk progenitors to IL-6 in vitro, current results suggest that the role of IL-6 may be mainly mediated by sIL-6R, and that the
gp130 signaling
initiated by the sIL-6R/
IL-6 complex is involved in human megakaryopoiesis in vivo
Gaillard et al., Eur Cytokine Netw 1999
(Paraproteinemias) :
Soluble
gp130 had already been shown to
inhibit IL-6 signaling by inactivating the IL-6/IL-6R complex
Haggiag et al., FEBS Lett 1999
:
Activation of
gp130 signaling by
IL6RIL6 appears comparable to cyclic AMP elevating agents to induce the myelin gene products in DRG and in pure Schwann cell cultures
Xie et al., Leuk Res 1999
:
Furthermore,
activation of the PMA induced
gp130 receptor by exogenous
IL-6 potentiated the differentiating effects of PMA
Xie et al., Cancer Lett 2000
(Leukemia, Promyelocytic, Acute) :
Furthermore,
activation of the RA-induced
gp130 by exogenous
IL-6 potentiated the differentiating effects of RA
Müllberg et al., J Immunol 2000
(Sarcoma, Kaposi) :
IL-6 receptor independent
stimulation of human
gp130 by viral
IL-6
Pflanz et al., J Immunol 2000
:
On the basis of our data, a model for the mechanism of
IL-6 induced
gp130 activation is proposed
Matsui et al., Int J Hematol 2000
:
We have reported that simultaneous
activation of
glycoprotein (gp) 130 and c-kit signals by
interleukin (IL)-6 , soluble IL-6 receptor ( sIL-6R ), and stem cell factor (SCF) promotes proliferation of human hematopoietic progenitor cells and their differentiation into erythroid, myelocytic, and megakaryocytic cells
Gunaje et al., Mol Cell Biol Res Commun 2000
(MAP Kinase Signaling System) :
We demonstrate that exposure of CCL39 cells to TGF-beta completely inhibits
IL-6 induced Stat3 tyrosine phosphorylation and
gp130 gene expression
Shuto et al., Neuroreport 2001
:
In contrast,
IL-6 enhanced the mRNA expression of
gp130 and CNTF
Schaeffer et al., Mol Cell Biol 2001
:
Interleukin-6 (IL-6) induces the activation of the Src family kinase Hck, which is associated with the IL-6 receptor beta-chain,
gp130
Ling et al., Crit Care Med 2002
:
In endotoxin treated rats, there was significant inhibition of
interleukin-6 activation of janus kinase-1,
gp 130 , the interleukin-6 receptor, STAT1, and STAT3
Naka et al., Arthritis Res 2002
(Arthritis, Rheumatoid...) :
IL-6 signaling is
mediated exclusively by the common signal transducing component
gp130 , which is also essential for signal transduction of other cytokines of the leukemia inhibitory factor (LIF)/IL-6 family
Tebbutt et al., Nat Med 2002
(Adenoma...) :
In contrast, mice harboring the reciprocal mutation ablating STAT1/3 signaling ( gp130 ( Delta STAT ) ), or deficient in
IL-6 mediated
gp130 signaling ( IL-6 ( -/- ) mice ), showed impaired colonic mucosal wound healing
Kishimoto et al., J Autoimmun 1992
(Arthritis, Rheumatoid) :
Binding of
IL-6 to IL-6R
triggers the association of IL-6R and
gp130 , and gp130 in turn transduces the signal
Leu et al., Oncogene 2003
(Esophageal Neoplasms) :
IL-6 stimulation
induced a rapid phosphorylation of
gp130 and STAT3, and a dominant negative STAT3 completely abolished the antiapoptotic effect
Kovacs et al., Biomed Pharmacother 2003
(Multiple Myeloma) :
How does
interleukin-6 affect the membrane expressions of interleukin-6 receptor and
gp130 and the proliferation of the human myeloma cell line OPM-2 ? ... This is the first report that
IL-6 inhibits the membrane expression of
gp130 , although the proliferation of the myeloma cells increases
Omori et al., J Biol Chem 2004
:
Consistent with the expression of its mRNA, the HG condition also increased the expression of
gp130 protein, and phosphorylation of the tyrosine residue by gp130 was
enhanced significantly by
IL-6/sIL-6R stimulation
Zhou et al., Int J Hematol 2004
(Multiple Myeloma) :
In CD45+ U266 cells,
IL-6 increased tyrosine phosphorylation of
gp130 and STAT3 and stimulated the level of Mcl-1 protein expression
Wang et al., J Invest Dermatol 2004
:
Application of the fusion protein
gp130-FC , a specific
inhibitor of the agonist
IL-6/sIL-6 receptor complex, delayed barrier repair in wild, but not in IL-6-deficient mice
Zancai et al., Int J Oncol 2004
:
These changes, however, were not related to the enhanced production of endogenous IL-6 induced by RA in LCLs. RA-induced modulation of IL-6 receptor components did not abolish
IL-6 mediated phosphorylation of
gp130 , whereas JAK1 and STAT3 phosphorylation and activation induced by IL-6 were markedly inhibited
Saito et al., J Immunol 1992
:
Both
gp130 and IL-6R mRNA in liver were
up-regulated in vivo by
IL-6
Nishimichi et al., Dev Comp Immunol 2006
:
IL-6 signaling is
regulated by two receptors, a specific alpha chain ( IL-6Ralpha ) and a signal transducer,
gp130
Kishimoto et al., Int J Immunopharmacol 1992
:
Binding of IL-6 to
IL-6R triggers the association of IL-6R and
gp130 , and gp130 in turn transduces the signal ... NF-IL6 is also involved in the transcriptional regulation of various acute phase protein genes IL-6 triggered association of IL-6R and
gp130 on hepatocytes, through intermediate steps including serine-phosphorylation of pre existing NF-IL6 protein,
leads to binding of
NF-IL6 to IL-6-responsive elements and activation of acute-phase protein genes
Robb et al., Proc Natl Acad Sci U S A 2005
(Inflammation) :
Mice lacking SOCS3 die at midgestation because of placental failure, and SOCS3 ablation in a cell-type-specific manner results in changes in the functional outcome of
gp130 signaling in
response to
IL-6
Mitsuyama et al., Gut 2006
(Disease Models, Animal...) :
We also examined the effects of intravenously injected hyper-IL-6, an IL-6/soluble IL-6 receptor fusion protein, and of soluble
gp130-Fc , a specific
inhibitor of soluble
IL-6 receptor signalling, on STAT3 phosphorylation and disease severity in SAMP1/Yit mice
Kovacs et al., TheScientificWorldJournal 2006
(Lymphoma, B-Cell...) :
In this study, we investigated the
effects of
IL-6 , IL-6 receptor antagonist (IL-6RA), and gp130 antagonist (gp130A) on the membrane expressions of IL-6R and
gp130 , on the viability, on the proliferation, on the DNA synthesis, and on the cell cycle phases in several multiple myeloma ( MM ) cell lines and B cell lymphoma cell lines
Cronstein et al., Bull NYU Hosp Jt Dis 2007
(Arthritis, Rheumatoid) :
Il-6 signaling
involves both a specific IL-6 receptor (IL-6R) and a ubiquitous signal transducing protein,
gp130 that is also utilized by other members of the IL-6 family
Tanaka et al., Mol Cell Biol 2008
:
Here we found that
IL-6 stimulation
induced lysosome dependent degradation of
gp130 , which correlated with an increase in the K63 linked polyubiquitination of gp130 ... We also found that
IL-6 induced a rapid translocation of
gp130 from the cell surface to endosomal compartments
Kulikov et al., Genes, brain, and behavior 2010
(Catalepsy) :
Glycoprotein
gp130 is
involved in the
interleukin-6 (IL-6) and related cytokines ' signaling
Kobayashi et al., Mol Biotechnol 2011
:
ELISAs revealed that RA07 could not inhibit
IL-6 from binding to the IL-6 receptor (IL-6R), but could
inhibit the IL-6/IL-6 complex binding to
gp130
Lee et al., J Immunol 2011
(Fetal Membranes, Premature Rupture...) :
Soluble
gp130 ( sgp130 ) selectively
inhibits IL-6 trans signaling
Burton et al., Journal of neuroinflammation 2011
:
Soluble
gp130 attenuated
IL-6- and LPS stimulated IL-6 receptor (IL-6R) activation along with IL-6 protein release in both microglial ( BV.2 ) and neuronal ( Neuro.2A ) cell types in vitro
Silver et al., J Immunol 2011
(Genetic Predisposition to Disease...) :
Collectively, these studies highlight that a failure to abbreviate
IL-6 mediated
gp130 signaling results in a profound anti-inflammatory signal that blocks the generation of protective immunity to T. gondii
Garbers et al., J Biol Chem 2011
:
Soluble
gp130 ( sgp130 ) specifically
inhibits IL-6 trans signaling but was described to not interfere with classic signaling via the membrane bound IL-6R
Taga et al., Cell 1989
:
In fact, a soluble IL-6-R lacking the transmembrane and intracytoplasmic domains can associate with
gp130 in the
presence of
IL-6 and mediate its function
De Serio et al., J Mol Biol 1995
:
While
IL-6 induces gp130 dimerization, CNTF, after the initial interaction with the specific, non signalling receptor subunit, CNTFR,
induces the formation of
gp130/LIF-receptor heterodimers
Matsuda et al., Blood 1995
:
In this study we show that in addition to Jak family tyrosine kinase, the
stimulation of
gp130 by
IL-6 plus soluble IL-6 receptor alpha induced the activation of Btk and Tec tyrosine kinases, whereas IL-3 and granulocyte colony stimulating factor activated Tec but not Btk in a pro-B cell line
Wang et al., Gene 1995
(Acute-Phase Reaction) :
Metabolic labeling, using [ 32P ] orthophosphate or anti-phosphotyrosine antibody ( Ab ) blot experiments revealed that both
IL-6 and CNTF
induced tyrosine phosphorylation of
gp130 , and the Jak1 and Jak2 kinases in a dose- and time dependent manner
Saito et al., J Immunol Methods 1993
:
Some of the mAbs inhibited the
IL-6 induced association of soluble
gp130 and soluble IL-6 receptor
Schwabe et al., J Clin Invest 1994
(Multiple Myeloma) :
Second, IFN-alpha induced
IL-6 predominantly
down-regulated membrane bound
gp130
Murakami et al., Science 1993
:
IL-6 induced homodimerization of
gp130 and associated activation of a tyrosine kinase ... The
IL-6 induced
gp130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor (LIF) receptor ( LIFR ) and gp130 in response to the LIF or ciliary neurotrophic factor (CNTF)
Kang et al., Cell Immunol 1996
(Multiple Myeloma) :
Interestingly, the presence of okadaic acid induced the up-regulation of IL-6 receptor expression as well as the down-regulation of
IL-6 induced
gp130 phosphorylation in the myeloma cells
Ikeda et al., Brain Res 1996
(Disease Progression...) :
IL-6 triggers homodimerization of
gp130 , whereas CNTF and LIF induce heterodimerization of gp130 and LIF receptor
Berger et al., Blood 1997
(Multiple Myeloma) :
IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal transducing subunit
gp130 , the gp130 associated protein tyrosine kinases Jak1, Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen activated protein kinase Erk2, and accumulation of GTP bound p21ras ... Prior treatment of U266 cells with IFN-beta downregulated
IL-6 induced tyrosine phosphorylation of
gp130 , Jak2, PTP1D/Syp, Shc, and Erk2, and GTP loading of p21ras
Simpson et al., Protein Sci 1997
(Arthritis, Rheumatoid...) :
Like the other members of this family,
IL-6 induces growth or differentiation via a receptor-system that involves a specific receptor and the use of a shared signaling subunit,
gp130
Ogata et al., J Immunol 1997
(Multiple Myeloma) :
IL-6 induced phosphorylation of JAK kinases and
gp130 , regardless of the proliferative response of MM cells to this growth factor
März et al., Eur J Neurosci 1997
:
Interleukin-6 (IL-6) on target cells binds to the specific IL-6 receptor (IL-6R) and subsequently
induces homodimerization of the signal transducing protein
gp130
Dahmen et al., Biochem J 1998
:
Taken together, our data support the concept that
IL-6 and IL-11
activate gp130 by very similar molecular mechanisms
Hammacher et al., J Biol Chem 1998
:
The data suggest that gp130-activation by IL-6 and LIF requires different regions of gp130, that the Ig-like module of gp130 may be required for
IL-6 induced
gp130 dimerization, and that the stoichiometry of the high affinity IL-6 receptor-complex differs from those of the receptor-complexes for LIF and OSM