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E2F4 — E2F7
Text-mined interactions from Literome
Smith et al., J Biol Chem 2000
:
The postconfluent dividing cells share features with cells that normally exit the cell cycle ; p27 ( kip1 ) is
increased , p21 ( waf1/cip1 ) is decreased, free
E2F DNA binding activity is reduced, and
E2F4 is primarily nuclear
Di Stefano et al., EMBO J 2003
:
Interestingly, however,
E2F7 binds only a subset of E2F dependent promoters in vivo, and in agreement with this, inhibition of
E2F7 expression
results in specific derepression of these promoters
Dingar et al., J Mol Cell Cardiol 2012
:
As analyzed by chromatin immunoprecipitation, the
E2F4-p130-repressor directly
blocks transcription of essential apoptosis related genes,
E2F1 , Apaf-1, and p73a through recruitment of histone deacetylase 1 (HDAC1)