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MYLIP — NFKB1
Text-mined interactions from Literome
Taganov et al., Proc Natl Acad Sci U S A 2006
:
NF-kappaB dependent induction of microRNA
miR-146 , an inhibitor targeted to signaling proteins of innate immune responses
Chen et al., Oncogene 2008
(Ovarian Neoplasms) :
Regulation of IKKbeta by
miR-199a affects
NF-kappaB activity in ovarian cancer cells
Wang et al., Cancer Cell 2008
(Rhabdomyosarcoma) :
Results demonstrate that in myoblasts,
miR-29 is
repressed by
NF-kappaB acting through YY1 and the Polycomb group
Bazzoni et al., Proc Natl Acad Sci U S A 2009
(Inflammation) :
Among the 3 different genes encoding miR-9 precursors in humans, we show that LPS selectively induces the transcription of
miR-9-1 located in the CROC4 locus, in a MyD88- and
NF-kappaB dependent manner ... In PMN and monocytes, LPS regulates NFKB1 at both the transcriptional and posttranscriptional levels, and a conserved miR-9 seed sustained a
miR-9 dependent inhibition of the
NFKB1 transcript ... Overall, these data suggest that TLR4 activated
NF-kappaB rapidly
increases the expression of
miR-9 that operates a feedback control of the NF-kappaB dependent responses by fine tuning the expression of a key member of the NF-kappaB family
Xiao et al., J Infect Dis 2009
(Helicobacter Infections...) :
H. pylori was able to increase the miR-155 expression in gastric epithelial cell lines and gastric mucosal tissues, and
nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) pathway were
required for the induction of
miR-155
Liu et al., Proc Natl Acad Sci U S A 2009
(Inflammation) :
Expression of miR-147 was greater after cellular activation by TLR4 than after engagement of either TLR2 or TLR3, suggesting that maximal induction of
miR-147 required activation of both
NF-kappaB and IRF3
Ohdaira et al., Comput Biol Chem 2009
(Lung Neoplasms) :
Using a luciferase reporter assay, we also showed that
hsa-miR-601 specifically
repressed nuclear factor-kappaB (NF-kappaB) transcription factor dependent reporter expression, a key component of the immune-oncogenesis pathway
Gao et al., Cancer 2010
(Adenocarcinoma...) :
Overexpression of
miR-218 also
inhibited NF-kappaB transcriptional activation and transcription of cyclooxygenase -2, a proliferative gene regulated by NF-kappaB
Marquez et al., Am J Physiol Gastrointest Liver Physiol 2010
:
It has been previously reported that
NF-kappaB upregulates the
miR-21 precursor transcript ... Using NF-kappaB reporter assays, we determined that
miR-21 overexpression
inhibits NF-kappaB signaling
Jurkin et al., J Immunol 2010
(Bacterial Infections) :
Inversely, silencing of
miR-146a in LCs
enhanced TLR2 dependent
NF-kappaB signaling
Mott et al., J Cell Biochem 2010
:
Finally, activation of
NF-kappaB signaling, via ligation of Toll-like receptors, also
repressed mir-29b expression and promoter function
Xu et al., J Biol Chem 2011
:
miR-365 , a novel negative regulator of interleukin-6 gene expression, is cooperatively
regulated by Sp1 and
NF-kappaB
Ghose et al., PloS one 2011
(Huntington Disease) :
Regulation of
miR-146a by
RelA/NFkB and p53 in STHdh ( Q111 ) /Hdh ( Q111 ) cells, a cell model of Huntington 's disease ... We conclude that ( i ) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions ; ( ii ) reduced miR-125b and miR-150 expressions, increased p53 level and decreased
RelA/NFkB and miR-146a expressions originate from mutant HTT ( iii ) p53 directly or indirectly
regulates the expression of
miR-146a
Li et al., BMC molecular biology 2012
(Esophageal Neoplasms) :
Reporter assay further showed that
NF-kappaB induced
miR-34a transcriptional activity was reduced by p53 impairment
Crone et al., Molecular cancer 2012
(Disease Models, Animal...) :
Lysophosphatidic acid (LPA) induces
NF-kappaB activation via this pathway and over-expression of
miR-146a inhibited LPA induced NF-kappaB activation, reduced LPA induced expression of tumor promoting cytokines and growth factors and inhibited monocyte attraction
Panguluri et al., PloS one 2013
(Diabetes Mellitus...) :
This
miR-301 mediated regulation of Kv4.2 is
independent of
NFkB and Irx5 and modulates Kv4.2 by direct binding on Kv4.2 3'untranslated region ( 3'-UTR )