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IL6 — TLR4
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IL6
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TLR4
(increases, IL6 Activity)
Zeuke et al., Cardiovasc Res 2002*
Evidence: We tested if human coronary artery endothelial cells (HCAEC) may become a source of cytokine and adhesion molecule expression when stimulated with bacterial lipopolysaccharide (LPS). Analysis of HCAEC supernatants by ELISA identified enhanced secretion of IL-6, IL-8, and MCP-1 while
Text-mined interactions from Literome
Supajatura et al., J Immunol 2001
(Acute Disease...) :
Using BMMCs from the genetically TLR4 mutated strain C3H/HeJ, we demonstrated that functional
TLR4 was
required for a full responsiveness of BMMCs to produce inflammatory cytokines ( IL-1beta, TNF-alpha,
IL-6 , and IL-13 ) by LPS stimulation
McCurdy et al., J Leukoc Biol 2001
:
Using these models, we demonstrated that the BMMC
IL-6 and TNF-alpha responses to LPS were completely
dependent on functional
TLR4 with no significant LPS response observed in its absence
Schilling et al., J Immunol 2002
:
Toll-like receptor 4 and Toll-IL-1 receptor domain containing adapter protein ( TIRAP ) /myeloid differentiation protein 88 adapter-like ( Mal )
contribute to maximal
IL-6 expression in macrophages ... In this study, we show that
IL-6 expression is also preferentially
induced by activation of
TLR4 ...
TLR4 dependent
induction of
IL-6 expression did require Toll-IL-1R domain containing adapter protein ( TIRAP ) /MyD88 adapter-like (Mal), but unlike iNOS and IP-10, it did not require the expression of IFN-beta
Tamandl et al., Shock 2003
(Inflammation...) :
Here, we evaluated
TLR-4 expression of isolated monocytes in the
presence of tumor necrosis factor (TNF)-alpha,
interleukin (IL) 6 , IL-8, and IL-10, and we investigated cellular activation of this treatment
Huang et al., Nat Immunol 2004
:
MEKK3 forms a complex with TRAF6 in response to IL-1 and lipopolysaccharide (LPS) but not CpG, and is required for IL-1R- and
TLR4 induced
IL-6 production
Braedel et al., Br J Haematol 2004
:
The release of IL-12 by BMDCs in response to A. fumigatus antigens was dependent on the expression of TLR2, whereas the release of
IL-6 was
dependent on the expression of functional
TLR4 molecules
Brito et al., Exp Eye Res 2004
:
Incubation of explants with a neutralizing anti-toll-like receptor-4 monoclonal antibody was used to determine if lipopolysaccharide stimulation of tumor necrosis factor or
interleukin-6 secretion was
dependent on
Toll-like receptor-4 activity
Kurt-Jones et al., J Endotoxin Res 2004
:
MEFs were highly responsive to TLR-ligand activation and secreted high levels of both
IL-6 and MCP-1 in
response to
TLR ligands
Goral et al., J Immunol 2005
(Inflammation) :
Furthermore, different
TLR ligands
stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Seki et al., Hepatology 2005
:
However,
TLR2 , 4 and 9, which recognize gram negative and -positive bacterial products, are not
essential for NF-kappaB activation and
IL-6 production after PH, which excludes a possible contribution of TLR2/TLR4 or TLR9 to MyD88 mediated pathways
Suliman et al., FASEB J 2005
:
In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with
TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ),
interleukin 6 , nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Zhang et al., EMBO J 2006
:
We found that the serine phosphorylation was crucial for
TLR induced
interleukin 6 production and this process is regulated by TRAF6, a key adaptor molecule for the TLR pathway
Machida et al., J Virol 2006
(Hepatitis C) :
The increased IFN-beta and
IL-6 production was
mediated by
TLR4 induction, since the introduction of the small interfering RNA against TLR4 specifically inhibited the HCV induced cytokine production
Kuwata et al., Immunity 2006
(Colitis...) :
IkappaBNS-deficient macrophages and dendritic cells show increased
TLR mediated expression of genes such as
IL-6 and IL-12p40, which are induced late after TLR stimulation
Kramer et al., J Leukoc Biol 2006
(Crohn Disease) :
Moreover, they lack MDP induced enhancement of
TLR mediated tumor necrosis factor alpha,
interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Horwood et al., J Immunol 2006
:
Furthermore, using the p38 inhibitor SB203580, we show that the
TLR4 induced production of TNF, but not
IL-6 , requires the activity of p38 MAPK
Baruah et al., J Leukoc Biol 2006
:
C1q increases the phagocytosis of apoptotic cells by DC and the release of
interleukin-12 in the
presence of
TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Jou et al., Am J Pathol 2006
(Inflammation) :
Transient transfection of dominant negative
TLR4 also
attenuated NF-kappaB binding activity and
interleukin-6 promoter activity
Song et al., Biochem Biophys Res Commun 2006
(Insulin Resistance) :
In addition, activation of
TLR4 with either LPS or free fatty acids
stimulated NFkappaB signaling and expression of inflammatory cytokine genes, such as TNFalpha and
IL-6 in 3T3-L1 adipocytes
Shahrara et al., J Immunol 2006
(Arthritis, Rheumatoid...) :
Because endogenous TLR4 ligands are expressed in the rheumatoid joint, the TLR4 ligand LPS was used to characterize the effects of RANTES on the
TLR4 mediated
induction of TNF-alpha and
IL-6 ... In conclusion, the results of this study suggest that RANTES down-regulates
TLR4 ligation
induced IL-6 and TNF-alpha secretion by enhancing IL-10 production in PB monocytes
Broad et al., Immunology 2007
:
In this study we have shown that, whilst NF-kappaB activation and production of TNF-alpha and
interleukin-12 by murine RAW264.7 and J774.2 cells in response to stimulation by TLR4, -5, -7 or -9, was
reduced by prior stimulation with
TLR4 , -5, -7 or -9 ligands, the primary stimulation of TLR3, which does not use the MyD88 pathway, did not reduce the TNF-alpha or interleukin-12 responses to subsequent TLR stimulation
Boyd et al., Cardiovasc Res 2006
(Myocarditis) :
Ligand activation of TLR2,
TLR4 and TLR5, but not TLR3, TLR7 or TLR9,
resulted in cardiomyocyte expression of the inflammatory cytokine
IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1 ... Ligand activation of TLR2,
TLR4 and TLR5, but not TLR3, TLR7 or TLR9,
resulted in cardiomyocyte expression of the inflammatory cytokine
IL-6 , the chemokines KC and MIP-2, and the cell surface adhesion molecule ICAM-1
Wang et al., Blood 2007
:
Here we demonstrate that Rab7b can negatively
regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha,
IL-6 , nitric oxide, and IFN-beta, and potentiate LPS induced activation of mitogen activated protein kinase, nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of
TLR4
Inoue et al., Immunopharmacol Immunotoxicol 2007
(Hemorrhage...) :
Role of
interleukin-6 in
toll-like receptor 4 and 2 expressions induced by lipopolysaccharide in the lung ... The present study elucidated the
role of
IL-6 in
Toll like receptor (TLR) 4 and 2 expressions in the lung during inflammation induced by intraperitoneal administration of LPS ( 1 mg/kg ) using IL-6 null ( -/- ) mice and wild type ( WT ) mice
Shu et al., Clin Exp Immunol 2007
:
natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha,
interleukin (IL)-6 and IL-12 p40 in
response to
Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Batra et al., Am J Pathol 2007
:
In WT preadipocytes the
TLR responsiveness
increased during maturation to adipocytes ; however, stimulation of ob/ob and db/db cells resulted in a 10- to 20-fold higher
interleukin-6 production
Aprahamian et al., J Pediatr Surg 2007
(Inflammation...) :
Hepatic messenger RNA levels of
IL-6 ( 12.8-fold change [ FC ] ) and tumor necrosis factor alpha ( 5.65 FC ) were elevated in SBS vs SH rats ; and IL-6 ( 114 FC ), tumor necrosis factor alpha ( 3.87 FC ), and
Toll-like receptor 4 ( 7.65 FC ) were
increased in SBS/sepsis compared with SH/sepsis animals
Barr et al., Eur J Immunol 2007
:
In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the
role of
Toll-like receptors ( TLR ) in the control of secretion of
IL-6 , IL-10, IL-12 and IFN-gamma by B cells
Sawa et al., J Histochem Cytochem 2008
:
The LPS induced
IL-6 , IL-8, VCAM-1, and ICAM-1 production in LEC was
suppressed by the introduction of TLR4-specific small interfering RNA, and also by
anti-TLR4 , nobiletin, and CAPE pretreatment
Lapteva et al., Cancer Res 2007
:
Whereas neither iCD40 nor
TLR-4 signaling alone
led to high levels of interleukin (IL)-12p70 and
IL-6 , using iCD40 in combination with lipopolysaccharide (LPS) or monophosphoryl lipid A led to strongly synergistic production of both
Wilson et al., Cell Microbiol 2008
:
Production of TNF-alpha and
IL-6 was
dependent on expression of
TLR4 as stimulation of macrophages from TLR4 ( -/- ) mice with S. Typhimurium did not result in expression of these cytokines
Villacres et al., J Viral Hepat 2008
(Hepatitis C, Chronic) :
Interleukin (IL)-6 in
response to TLR3 and
TLR4 ligands such as polyinosinic-polycytidylic acid and lipopolysaccharide was significantly compromised in HCV infected women
Son et al., J Cardiovasc Pharmacol 2008
:
However, it is unknown how
TLR-4 regulates
interleukin-6 (IL-6) in VSMC ... Therefore, the present study investigated cellular factors involved in
TLR-4 mediated
IL-6 in VSMC in terms of MAPK and transcription elements
Yu et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2007
(Pneumonia...) :
Ketamine at sub-anesthetic doses could suppress the production of inflammatory cytokines such as TNF-alpha and
IL-6 , attenuate NF-kappaB activity, and
inhibit TLR2 and
TLR4 expression in polymicrobial sepsis
Taneichi et al., Clin Immunol 2008
(Agammaglobulinemia...) :
Stimulation with TLR2,
TLR4 and TLR7/8 ligands, as well as TLR3 ligand,
resulted in significantly lower production of TNF-alpha, but neither
IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Sun et al., Mol Immunol 2008
(Colonic Neoplasms...) :
Suppression of
TLR4 induced
IL-6 and PGE ( 2 ) production is responsible for the rapamycin mediated decrease of TLR4 evoked invasion of colon cancer cells ... Furthermore, disruption of NF-kappaB pathway contributes to the inhibition of
TLR4 induced
IL-6 , PGE ( 2 ) production and invasion by rapamycin in colon cancer cells
Prescott et al., J Allergy Clin Immunol 2008
(Hypersensitivity...) :
Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and
IL-6 responses to TLR2,
TLR4 , and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Hoth et al., Shock 2009
(Contusions...) :
Increased expression of
IL-6 and chemokine ( C-X-C motif ) ligand 1 in the bronchoalveolar lavage and serum was also
dependent on
TLR-4 activation
Jiang et al., Virology 2008
(Hemorrhagic Fever with Renal Syndrome) :
The increased IFN-beta,
IL-6 and TNF-alpha production was
mediated by
TLR4 induction, since the introduction of the small interfering RNA against TLR4 specifically inhibited the HTNV induced cytokine production ... In conclusion, HTNV infection directly
induces TLR4 expression and thereby enhanced production of IFN-beta,
IL-6 and TNF-alpha, which may contribute to the host 's innate immune response
Castillo et al., Nanomedicine (Lond) 2008
:
Ag @ tiopronin nanoparticles were not proinflammatory agents, but remarkably they specifically impaired the
IL-6 secretion
mediated by TLR2,
TLR2/6 , TLR3 or TLR9 stimulation in co-treatment experiments
Xie et al., Pediatr Res 2009
:
Altogether, our studies indicated that
TLR4 play a critical role in leading LPS
mediated-IL-6 response in RSV infected-epithelial cells and might be an important factor influencing the cytokine-chemokine profile of epithelial cells interacting with virus and endotoxin, which is correlated with phenotypes of RSV diseases
Mencarelli et al., Am J Physiol Heart Circ Physiol 2009
(Atherosclerosis...) :
FXR activation by natural and synthetic ligands in these cell types attenuated IL-1beta,
IL-6 , and TNF-alpha gene induction in
response to
Toll-like receptor 4 activation by LPS
Abdollahi-Roodsaz et al., Arthritis Rheum 2008
(Arthritis, Infectious...) :
Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with
TLR-4 mediated
interleukin-17 production
Ospelt et al., Arthritis Rheum 2008
(Arthritis, Rheumatoid...) :
Among the expressed TLRs,
TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C )
led to the most pronounced increase in
IL-6 , MMP-3, and MMP-13 ... Among the expressed TLRs, TLR-3 and
TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C )
led to the most pronounced increase in
IL-6 , MMP-3, and MMP-13
Mishra et al., Immunobiology 2009
:
Our findings suggest that RAE
induces TLR-4 expression and intracellular granzyme-B in treated splenocytes while RAE stimulated IL-1beta,
IL-6 , and TNF-alpha in human PBMCs
Matsushita et al., Nature 2009
(Anemia...) :
Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of
interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF, in
response to
TLR ligands
Hammad et al., Nat Med 2009
(Asthma...) :
TLR4 triggering on structural cells
caused production of the innate proallergic cytokines thymic stromal lymphopoietin, granulocyte-macrophage colony stimulating factor,
interleukin-25 and interleukin-33
Marsh et al., J Neurosci 2009
(Infarction, Middle Cerebral Artery...) :
TLR4 can
induce both IFNbeta and interferon stimulated genes through its adapter molecule
Toll/interleukin receptor domain containing adaptor inducing IFNbeta ( TRIF ) and the IRF3 transcription factor
Wu et al., Toxicol Lett 2009
(Inflammation) :
This study used RNA interference techniques to show that
TLR4 can
mediate LPS induced macrophage activations of IL-1beta and
IL-6 gene expression, chemotaxis, phagocytosis, and oxidative ability
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon (IFN)-gamma,
interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Lanz et al., Stem Cells Dev 2010
(Encephalomyelitis, Autoimmune, Experimental) :
This failure to catabolize trp is not due to defective TLR signaling as demonstrated by
induction of
interleukin 6 (IL-6) by
TLR activation
Frazier et al., J Immunol 2009
(Escherichia coli Infections...) :
MAPKs are crucial for TNF-alpha and
IL-6 production by innate immune cells in
response to
TLR ligands
Suzuki et al., J Dent Res 2009
(Gingival Overgrowth) :
In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of
interleukin (IL)-6 and IL-8
induced by
TLR ligands, whereas phenytoin attenuated those responses
Riddell et al., J Immunol 2010
:
In the current study, we demonstrate that incubation of Prx1 with thioglycollate elicited murine macrophages or immature bone marrow derived dendritic cells resulted in
TLR4 dependent secretion of TNF-alpha and
IL-6 and dendritic cell maturation
Sheng et al., Acta Cardiol 2009
(Dilatation, Pathologic...) :
The expression of TLR4, TNF-alpha and
IL-6 in the myocardium significantly
increased in the MI group and simvastatin markedly inhibits the expression of
TLR4 , TNF-alpha, and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged
Hoshino et al., J Leukoc Biol 2010
(MAP Kinase Signaling System) :
HIV-1 Vpr induces
TLR4/MyD88 mediated
IL-6 production and reactivates viral production from latency
Fang et al., FEMS Immunol Med Microbiol 2010
(West Nile Fever) :
Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or
toll-like receptor ( TLR ) agonist treatment of gammadelta T cells
induced the production of IFN-gamma, tumor necrosis factor-alpha and
IL-6 , which are known to promote DC maturation
Hutchinson et al., Neuroscience 2010
:
Live imaging of TLR4 activation in RAW264.7 cells and
TLR4 dependent
interleukin-1 release from BV-2 microglia revealed that amitriptyline blocked TLR4 signaling
Amu et al., Scand J Immunol 2010
:
We found that CD25 ( + ) B cells secreted higher levels of
IL-6 , IL-10 and INFgamma in
response to different
TLR-agonists , and were better at presenting alloantigen to CD4 ( + ) T cells
Li et al., Wei Sheng Wu Xue Bao 2010
(Streptococcal Infections) :
The cell wall of Streptococcus mutans upregulated the expression of
TLR4 and
induced the production of inflammatory cytokines
IL-6 and IL-8, indicating that the expression of TLR4 of EAhy926 cells may elicit a TLR4 mediated innate immune response and contribute to production of inflammatory cytokines IL-6 and IL-8
Han et al., Vet Microbiol 2010
:
Involvement of
TLR21 in baculovirus induced
interleukin-12 gene expression in avian macrophage-like cell line HD11
Yin et al., Biochem Biophys Res Commun 2010
(Urinary Tract Infections) :
TLR4 promotes secretion of
IL-6 and IL-8, mediates inhibition of bladder epithelial cell ( BEC ) bacterial invasion, and mediates expulsion of uropathogenic Escherichia coli from BECs
Piconi et al., AIDS 2010
(HIV Infections) :
Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression,
interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V,
activation of caspases 8 and 9,
Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Gomez et al., Mediators Inflamm 2010
:
Aging or
IL-6 deficiency did not
affected the percentage of F4/80 ( + ) macrophages, or the surface expression of
Toll-like receptor 4 (TLR4) and components of the IL-6 receptor
Chung et al., J Infect Dis 2010
(Hepatitis C, Chronic) :
Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of
interleukin 17 by naive CD4 ( + ) T cells in the
presence of
TLR ligands
Hunter et al., TheScientificWorldJournal 2010
(Peritonitis) :
Selective inhibitors of Kv11.1 regulate
IL-6 expression by macrophages in
response to
TLR/IL-1R ligands
Jones et al., J Immunol 2010
:
We compared the ability of progesterone to modulate murine bone marrow derived DC cytokine production (
IL-6 and IL-12 ) and costimulatory molecule expression ( CD40, CD80, and CD86 )
induced by either TLR3 or
TLR4 ligation and determined whether activity was via the progesterone receptor (PR) or glucocorticoid receptor ( GR ) by comparative studies with the PR-specific agonist norgestrel and the GR agonist dexamethasone ... Progesterone was found to downregulate, albeit with different sensitivities, both TLR3- and
TLR4 induced
IL-6 production entirely via the GR, but IL-12p40 production via either the GR or PR
Foldi et al., J Immunol 2010
:
Jagged1 induction was augmented by IFN-?, was partially dependent on canonical TLR activated NF-?B and MAPK signaling pathways, and elevated Jagged1 expression augmented
TLR induced
IL-6 production
Chávez-Sánchez et al., Lipids in health and disease 2010
:
The activation of CD14,
TLR4 , and TLR2 by mmLDL
induces IL-1ß,
IL-6 , and IL-10 secretion in human monocytes and macrophages ... Blocking CD14 in monocytes inhibited secretion of interleukin (IL)-1ß ( 72 % ),
IL-6 ( 58 % ) and IL-10 ( 63 % ), and blocking
TLR4 inhibited secretion of IL-1ß by 67 %, IL-6 by 63 % and IL-10 by 60 %
Lavoie et al., J Infect Dis 2010
(Infant, Premature, Diseases...) :
Preterm neonates had globally attenuated
TLR stimulated
interleukin (IL)-6 , interferon-a, and, to a lesser extent, tumor necrosis factor-a responses but demonstrated relative preservation of anti-inflammatory IL-10 responses in monocytes and dendritic cell subtypes
Ariza et al., J Biol Chem 2011
:
Interestingly, activation of bone marrow derived dendritic cells ( in vitro with Bryo-1 ) led to a
TLR4 dependent biphasic activation of nuclear factor-?B ( NF-?B ) and the unique induction of cytokines ( IL-5,
IL-6 , and IL-10 ) and chemokines, including RANTES ( regulated on activation normal T cell expressed and secreted ) and macrophage inflammatory protein 1a ( MIP1-a )
Song et al., Leukemia 2011
:
LBH589 also significantly repressed the production of
interleukin (IL)-6 , IL-10, IL-12p70, IL-23 and tumor necrosis factor-a by Toll-like receptor (TLR)3 and
TLR4 induced DC
activation , indicating an important role of HDAC activity in immune regulation and inflammation
Li et al., Cardiovascular diabetology 2010
:
Stimulation of TLR2 or
TLR4 induced NF-?B activation, and the expression of ICAM-1,
IL-6 and IL-8
Agarwal et al., Arthritis Res Ther 2011
(Fibrosis...) :
The ability of IFNa2 to regulate
TLR induced
interleukin (IL)-6 and CC chemokine ligand 2 production was also assessed
Kim et al., Acta Diabetol 2013
(Glucose Intolerance...) :
IL-6 induction of
TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle ... To determine the main signaling pathway for
IL-6 induced
TLR-4 gene expression, we examined several signaling factors associated with IL-6 signaling pathways ...
IL-6 induction of
TLR-4 gene expression via STAT3 is one of the main mechanisms underlying insulin resistance in human skeletal muscle
El-Hage et al., Immunol Invest 2011
:
TLR3 and
TLR4 stimulation
increased the secretion of TNF-a,
IL-6 , and RANTES/CCL5, while activation of TLR2 caused a significant increase in nitric oxide levels
Vaquero et al., Hepatology 2011
:
CONCLUSION
: TLR-4 signaling
contributes to
IL-6 activation after PH, but the Tlr4 independent component appears sufficient for ensuring intact signaling downstream of IL-6
Chen et al., Kidney Int 2011
(Acute Kidney Injury...) :
Early
interleukin 6 production by leukocytes during ischemic acute kidney injury is
regulated by
TLR4
John et al., Exp Lung Res 2011
(Cystic Fibrosis) :
Nevertheless, cystic fibrosis ( CF ) airways are chronically infected with Pseudomonas aeruginosa, suggesting a modified immune response in CF. The authors have shown that in CF bronchial epithelial cells, a reduced surface expression of
TLR-4 causes a diminished interleukin (IL)-8 and
IL-6 response upon lipopolysaccharide (LPS) stimulation
Tang et al., Contrib Nephrol 2011
(Diabetic Nephropathies...) :
In human DN biopsies and PTEC,
TLR4is upregulated and
plays a permissive role in HG-induced
IL-6 and CCL-2 overexpression and monocyte transmigration
Séité et al., J Autoimmun 2011
(Autoimmune Diseases) :
As a result, IVIg suppresses
TLR induced production of the proinflammatory
IL-6 , but not that of the anti-inflammatory IL-10
Caraş et al., Roum Arch Microbiol Immunol 2011
:
As expected, induction of TNF-alpha and
IL-6 by TLR4 agonist LPS was
inhibited in a significant manner by
anti-TLR4 but not by anti-TLR2 antibody
Pietrzak et al., Mediators Inflamm 2011
:
Surface mast cell
TLR4 expression is
affected by LPS, LAM,
IL-6 , and CCL5
Chung et al., J Viral Hepat 2011
(Hepatitis B...) :
We previously showed that chronic exposure to the core antigen induces hyporesponsiveness to TLR ligands in antigen presenting cells via activation of TLR2 and that stimulation with
TLR ligands
results in impaired
IL-6 production by peripheral blood monocytes from HCV infected patients
Bromfield et al., Endocrinology 2011
(Inflammation) :
Targeting
TLR4 with small interfering RNA
attenuated granulosa cell accumulation of
IL-6 in response to LPS
Kane et al., Science 2011
(Pregnancy Complications, Infectious...) :
MMTV bound bacterial lipopolysaccharide triggered
Toll-like receptor 4 and subsequent
interleukin-6 (IL-6) dependent
induction of the inhibitory cytokine IL-10
Lin et al., J Am Soc Nephrol 2012
(Diabetes Mellitus, Experimental...) :
Silencing of
TLR4 with small interfering RNA attenuated high glucose induced I?B/NF-?B activation,
inhibited the downstream synthesis of
IL-6 and CCL-2, and impaired the ability of conditioned media from high glucose treated proximal tubule cells to induce transmigration of mononuclear cells
Jin et al., Mol Immunol 2011
(MAP Kinase Signaling System) :
Interestingly, results showed that while activation of either
TLR4 or TLR2/6 ( TLR2dimerized with TLR6 ), but not TLR2/1 ( TLR2dimerized with TLR1 ), significantly
increased IL-6 expression by U937 mononuclear cells, coactivation of TLR4 and TLR2/6, but not TLR4 and TLR2/1, led to a further augmentation on IL-6 expression by increasing IL-6 transcriptional activity, but not mRNA stability
Farrar et al., FASEB J 2012
(Disease Models, Animal...) :
Activation of
TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as
IL-6 and TNF-a
Jia et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2011
:
Pe-LPS can
induce the expression of
IL-6 in osteoblast MC3T3-E1 through CD-14 and
TLR-4 , but not TLR-2
Panda et al., J Reprod Immunol 2012
(Pre-Eclampsia) :
The expression of
TLR induced production of TNF-a, IFN-a,
IL-6 , and IL-12 were measured by multicolor flow cytometry
Hanamsagar et al., Trends Immunol 2012
:
TLR signaling
triggers the transcriptional activation of
pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Xia et al., J Pineal Res 2012
(Inflammation) :
As expected, melatonin inhibited
TLR4 mediated tumor necrosis factor alpha ( TNF-a ),
interleukin (IL)-1ß , IL-6, IL-8, and IL-10 in LPS stimulated macrophages
Siggs et al., Blood 2012
:
Neither the missense nor the null allele affected
TLR induced secretion of
IL-6
Villacres et al., J Infect Dis 2012
(HIV Infections...) :
Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß),
interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a)
responses to Toll-like receptor (TLR) 3 and
TLR4 stimulation
Lee et al., Invest Ophthalmol Vis Sci 2012
(Disease Models, Animal...) :
TLR4 inhibition decreased the severity of CFS and significantly
reduced the mRNA expression of IL-1ß,
IL-6 , and TNF
Zamora et al., Cytokine 2012
:
Even though
TLR-activation induced TNFa, IL-10 and
IL-6 production, only recombinant TNFa was able to downregulate CD36
Sjölinder et al., Infect Immun 2012
:
Interleukin-6 (IL-6) secretion was
dependent on activation of
TLR4 and required the TLR signaling adaptor protein MyD88
Yew et al., PloS one 2012
:
Inhibitory studies using antisense oligonucleotides or neutralizing antibodies indicate that
IL-6 induction by
TLR4/MD2 complex is important for the activation of endogenous CD14 which later acts in concert or synergy with TLR4/MD2 as a factor resulting in IL-8 gene expression
Kim et al., Microb Pathog 2013
:
In addition,
TLR4 was
required for the optimal production of
IL-6 , TNF-a, and IL-12 in BMDCs in response to A. baumannii
Cox et al., PloS one 2012
:
This prolonged increase in mRNA levels could be the result of an extended period of NF-?B nuclear localization and the concurrent absence of the NF-?B inhibitor, I?Ba, after stimulation with LTA plus Hb. Dynasore inhibition experiments indicate that an endocytosis dependent pathway is required for the
TLR4 dependent up-regulation of
IL-6 secretion following activation with LTA plus Hb
Li et al., eLife 2012
:
A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger
TLR13 dependent
interleukin-1ß production
Tang et al., PloS one 2012
:
Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the IL-10 and
IL-6 production is
mediated at least partly by the interaction of SEA with
TLR4 ; and ( 3 ) SEA attenuated IFN-? induced MHC class II expression at the transcriptional level
Koblansky et al., Immunity 2013
(Genetic Predisposition to Disease...) :
Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is
required for
interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013
(Disease Resistance...) :
Altogether, our results indicate the redundant and essential
role of nucleic acid sensing TLR3,
TLR7 and TLR9 in inducing
interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013
:
We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2, TLR3,
TLR4 , and TLR6 and that lipopolysaccharide (LPS) significantly
induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß),
Interleukin-6 (IL-6) , and Interleukin-8 (IL-8) )
Panchapakesan et al., PloS one 2013
(Diabetes Mellitus...) :
HG
induced expression of
Toll-like receptor-4 , increased nuclear deoxyribonucleic acid binding for nuclear factor kappa B ( NF-?B ) and activator protein 1, induced collagen IV expression as well as
interleukin-6 secretion all of which were attenuated with empagliflozin
Karrich et al., Blood 2013
:
Although IL-21 did not affect
TLR induced type I IFNs,
IL-6 , and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Sun et al., J Immunol 2013
:
In this study we identified the key transcriptional elements for regulation of miR-142 and its impact on
TLR4 mediated expression of
IL-6
Herath et al., PloS one 2013
(MAP Kinase Signaling System) :
METHODOLOGYPRINCIPAL FINDINGS : This study systematically investigated the effects of P. gingivalis LPS1435/1449 and LPS1690 on the expression of TLR2 and
TLR4 signal transduction and the
activation of pro-inflammatory cytokines
IL-6 and IL-8 in human gingival fibroblasts ( HGFs )
Giacomini et al., Eur J Immunol 2013
(Multiple Sclerosis, Relapsing-Remitting) :
Furthermore, in MS-derived PBMCs,
TLR7 mediated production of
IL-6 and the ex vivo expression of B-cell activating factor of the TNF family, two crucial cytokines for B-cell differentiation and survival, were induced by IFN-ß
Davalos et al., J Cell Biol 2013
(Inflammation) :
HMGB1 depletion, HMGB1 blocking antibody, or
TLR-4 inhibition
attenuated senescence associated
IL-6 secretion, and exogenous HMGB1 stimulated NF-?B activity and restored IL-6 secretion to HMGB1 depleted cells
Brancato et al., Wound Repair Regen 2013
(Disease Progression...) :
The accumulation of CCL2, CX3CL1, tumor necrosis factor-a,
interleukin (IL)-6 , IL-10, IL-12, and interferon-? in wound fluids was not
TLR4 dependent
Liu et al., J Neurosci 2013
:
In cultured neurons,
TLR7 activation
induced IL-6 and TNF-a expression through Myd88