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CDH1 — NOTCH1
Text-mined interactions from Literome
Schaeffer et al., Curr Biol 2004
:
Notch dependent
Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells
Raymond et al., BMC developmental biology 2006
:
Müller glia in the teleost retina have a complex response to local injury that includes some features of reactive gliosis ( up-regulation of glial fibrillary acidic protein, GFAP, and re-entry into the cell cycle ) together with dedifferentiation and re-acquisition of phenotypic and molecular characteristics of multipotent retinal progenitors in the CMZ ( diffuse distribution of
N-cadherin ,
activation of
Notch-Delta signaling, and expression of rx1, vsx2/Chx10, and pax6a ) along with characteristics associated with radial glia ( expression of brain lipid binding protein, BLBP )
Leong et al., J Exp Med 2007
(Breast Neoplasms) :
Jagged1 mediated
Notch activation
induces epithelial-to-mesenchymal transition through Slug induced repression of
E-cadherin ... Slug was essential for
Notch mediated repression of
E-cadherin , which resulted in beta-catenin activation and resistance to anoikis ... Slug was essential for
Notch mediated repression of
E-cadherin , which resulted in beta-catenin activation and resistance to anoikis
Saad et al., Int J Biochem Cell Biol 2010
(Cell Transformation, Neoplastic) :
Inhibition of
Notch activation, by concurrent exposure to DAPT during the induction of EMT
attenuated the decrease in
E-cadherin expression, limited the increase in alpha-SMA and MMP-2 and -9 expression and decreased Snail expression
Guichard et al., Nature 2010
:
In human endothelial cells, the two toxins act in a conserved fashion to block formation of Sec15 vesicles,
inhibit Notch signalling, and reduce
cadherin expression at adherens junctions