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EPHA3 — RHOA

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF) → RHOA/GTP complex (RHOA) (modification, activates) Shamah et al., Cell 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA forward signaling: Ephrin A1/EPHA1-4/Ephexin complex (EFNA1-EPHA2_EPHA1_EPHA3_EPHA4-NGEF) → RHOA/GDP complex (RHOA) (modification, activates) Shamah et al., Cell 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA forward signaling: Ephrin A5/EPHA3/Crk complex (EFNA5-EPHA3-CRK) → RHOA/GDP complex (RHOA) (modification, activates) Lawrenson et al., J Cell Sci 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GTP complex (RHOA) (modification, activates) Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A2/EPHA3-4-5-6-7 complex (EFNA2-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GDP complex (RHOA) (modification, activates) Gallo et al., J Cell Biol 2002
  Evidence: mutant phenotype
• NCI Pathway Database EPHA forward signaling: Ephrin A5/EPHA3-4-5-6-7 complex (EFNA5-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GTP complex (RHOA) (modification, activates) Wahl et al., J Cell Biol 2000
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database EPHA forward signaling: Ephrin A5/EPHA3-4-5-6-7 complex (EFNA5-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4) → RHOA/GDP complex (RHOA) (modification, activates) Wahl et al., J Cell Biol 2000
  Evidence: mutant phenotype, assay, other species
• Reactome Reaction: EPHA3 → RHOA (reaction) Wahl et al., J Cell Biol 2000, Dickson et al., Curr Opin Neurobiol 2001, Sahin et al., Neuron 2005

Text-mined interactions from Literome

Winning et al., Differentiation 2002 : These data argue that, in contrast to the case in retinal ganglion cells, EphA4 in early Xenopus embryos acts to inhibit RhoA , suggesting that this receptor may regulate Rho differently ( and therefore affect the cytoskeleton differently ) in neuronal and non-neuronal cells
Kim et al., J Biol Chem 2002 : Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain ... Furthermore, Etk disrupts the interaction between RhoA and Rho-GDI ( guanine nucleotide dissociation inhibitor ) and promotes the membrane translocation of RhoA