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FOS — MAP2K5
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Manna et al., Oncogene 1999
:
gamma-GCS also abolished the activation of
AP-1 induced by TNF and
inhibited TNF induced activation of JNK and
mitogen activated protein kinase kinase
Kamakura et al., J Biol Chem 1999
:
Moreover, the serum induced
c-Fos expression was markedly
inhibited by expression of dominant negative
MEK5
Manna et al., J Immunol 2000
:
Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents,
inhibited the TNF induced activation of transcription factor
AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and
mitogen activated protein kinase kinase
Huang et al., Biochem Biophys Res Commun 2003
:
Select point mutations in subdomain X impair MEKK2 phosphorylation of the MAP2Ks, MKK7 and
MEK5 , abolish MEKK2 induced
activation of the MAPKs, JNK1 and ERK5, and diminish MEKK2 dependent activation of an
AP-1 reporter gene
Ryborg et al., Acta Derm Venereol 2004
:
The effects on transglutaminase-1 and
AP-1 were
dependent on protein kinase C and
mitogen activated protein kinase kinase