Gene interactions and pathways from curated databases and text-mining

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FOS — MAP2K5

Text-mined interactions from Literome

Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Kamakura et al., J Biol Chem 1999 : Moreover, the serum induced c-Fos expression was markedly inhibited by expression of dominant negative MEK5
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Huang et al., Biochem Biophys Res Commun 2003 : Select point mutations in subdomain X impair MEKK2 phosphorylation of the MAP2Ks, MKK7 and MEK5 , abolish MEKK2 induced activation of the MAPKs, JNK1 and ERK5, and diminish MEKK2 dependent activation of an AP-1 reporter gene
Ryborg et al., Acta Derm Venereol 2004 : The effects on transglutaminase-1 and AP-1 were dependent on protein kinase C and mitogen activated protein kinase kinase