Zhu et al., Transplant Proc 2008
:
The costimulatory blockade down-regulated the expression of 2 Th1 cytokines ( interferon-gamma [ IFN-gamma ] and interleukin-2 [ IL-2 ] ) and 2 Th2 cytokines ( IL-4 and IL-10 ), reduced the numbers of graft infiltrating CD4+ and CD8+ lymphocytes, and inhibited the expression of both perforin/GrB and FasL in allografts
Lee et al., Phytother Res 2013
(Inflammation) :
GRb1 significantly reduced the upregulation of tumor necrosis factor-a, interleukin (IL)-1ß and IL-6 mRNA in the brain tissue at 4?h after LPS injection