Ward et al., J Biol Chem 2005
:
Depletion of CHMP5 by siRNA does not affect the distribution or morphology of early endosomes, lysosomes, or Golgi but does result in reduced degradation of the EGFR similar to silencing of LIP5
Langelier et al., J Virol 2006
:
Consistent with its expected role in MVB vesicle formation, ( i ) human ESCRT-II localized to endosomal membranes in a VPS4 dependent fashion and ( ii ) depletion of EAP20/ESCRT-II and CHMP6/ESCRT-III inhibited lysosomal targeting and downregulation of the epidermal growth factor receptor , albeit to a lesser extent than depletion of TSG101/ESCRT-I