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POU5F1 — TCL1A

Text-mined interactions from Literome

Hu et al., Cancer Res 2008 (Breast Neoplasms...) : The repression of Oct4 reduces Tcl1 expression and further down-regulates the level of p-Ser.473-Akt1
Wang et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : We further demonstrate that Oct4 overexpression induced activation of TCL1 , AKT, and ABCG2 to mediate chemoresistance, which can be overcome by addition of the PI3K/AKT inhibitor ; therefore, a direct pathway of Oct4-TCL1-AKT-ABCG2 or a combination of Oct4-TCL1-AKT with the AKT-ABCG2 pathway could be a potential new mechanism involved in liver cancer cell chemoresistance