◀ Back to ERBB2
ERBB2 — NRG2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
Complex of ERBB2-ERBB3
→
NRG2
(directlyIncreases)
Sweeney et al., J Biol Chem 2001*
Evidence: In MDA-MB-453 cells, NRG1beta acting through an ErbB2/ErbB3 heterodimer stimulated prolonged signaling of all pathways examined relative to NRG2beta acting through the same heterodimeric receptor species. Surprisingly, NRG1beta and NRG2beta also regulated partially overlapping but distinct sets of genes in these cells.
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OpenBEL Selventa BEL large corpus:
Complex of ERBB2-ERBB3
→
NRG2
(directlyIncreases)
Evidence: Figure 1 , ERBB receptors, ligands, dimers and downstream signalling pathways. a , Members of the epidermal growth factor (EGF) family of growth factors are ligands for the ERBB receptors. Ligand binding to ERBB receptors induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues within the cytoplasmic tail. These phosphorylated residues serve as docking sites for a range of proteins, the ...
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NCI Pathway Database ErbB receptor signaling network:
ErbB2 (ERBB2)
→
ErbB2/ErbB3/neuregulin 2 complex (ERBB2-ERBB3-NRG2)
(modification, collaborate)
Hobbs et al., Oncogene 2002
Evidence: assay, physical interaction
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NCI Pathway Database ErbB receptor signaling network:
ErbB2 (ERBB2)
→
neuregulin 2 (NRG2)
(modification, collaborate)
Hobbs et al., Oncogene 2002
Evidence: assay, physical interaction
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NCI Pathway Database ErbB receptor signaling network:
ErbB2/ErbB3/neuregulin 2 complex (ERBB2-ERBB3-NRG2)
→
ErbB3 (ERBB3)
(modification, collaborate)
Hobbs et al., Oncogene 2002
Evidence: assay, physical interaction
-
NCI Pathway Database ErbB receptor signaling network:
ErbB2/ErbB3/neuregulin 2 complex (ERBB2-ERBB3-NRG2)
→
neuregulin 2 (NRG2)
(modification, collaborate)
Hobbs et al., Oncogene 2002
Evidence: assay, physical interaction
-
Reactome Reaction:
ERBB2
→
NRG2
(indirect_complex)
-
Reactome Reaction:
ERBB2
→
NRG2
(reaction)
Borg et al., Nat Cell Biol 2000, Xu et al., J Biol Chem 2001, Vijapurkar et al., Exp Cell Res 2003, Citri et al., EMBO Rep 2004, Xu et al., Nature structural & molecular biology 2005, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Cao et al., Mol Cell Biol 2007, Kaushansky et al., Chem Biol 2008, Wada et al., Cell 1990, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Karunagaran et al., EMBO J 1996, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996
Text-mined interactions from Literome
Tal-Or et al., Prostate 2003
(Prostatic Neoplasms) :
Our results demonstrate that
NRG activates
ErbB-2/ErbB-3 heterodimers and induces cell death of LNCaP cells
Yuste et al., Cancer Res 2005
(Breast Neoplasms) :
Activation of
ErbB2 by overexpression or by transmembrane
neuregulin results in differential signaling and sensitivity to herceptin
Wehr et al., Nat Methods 2006
:
In a first biological application, we monitored
neuregulin induced
ErbB2/ErbB4 receptor tyrosine kinase heterodimerization
Monje et al., J Biol Chem 2008
:
Protein kinase A-mediated gating of
neuregulin dependent
ErbB2-ErbB3 activation underlies the synergistic action of cAMP on Schwann cell proliferation ... Two basic observations defined the synergistic action of PKA as `` gating '' for neuregulin-ErbB signaling : 1 ) the activation of PKA was not sufficient to induce S-phase entry or the activation of either
ErbB2 or ErbB3 ; and 2 ) the presence of
neuregulin was strictly
required to ignite ErbB activation and thereby ERK and Akt signaling ... However, PKA directly phosphorylated ErbB2 on Thr-686, a highly conserved intracellular regulatory site that was required for the PKA mediated synergistic enhancement of
neuregulin induced
ErbB2-ErbB3 activation and proliferation in SCs ... The gating action of PKA on
neuregulin induced
ErbB2-ErbB3 activation has important biological significance, because it insures signal amplification into the ERK and Akt pathways without compromising either the neuregulin dependence or the high specificity of ErbB signaling pathways
Schmukler et al., PloS one 2012
(MAP Kinase Signaling System...) :
Previously, it was demonstrated that
NRG activates
ErbB-2/ErbB-3 heterodimers to induce LNCaP cell death, whereas, EGF activates ErbB-1/ErbB-1 or ErbB-1/ErbB-2 dimers to induce cell growth and survival