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STAT1 — TLR2

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2003 : These studies show that engagement of TLR2 and TLR4 leads to rapid phosphorylation of the transcription factor STAT1 at serine 727 ( Ser-727 STAT1 ) in murine macrophages ... TLR induced phosphorylation of Ser-727 STAT1 could be blocked by the selective p38 mitogen activated protein kinase inhibitor SB203580 ... TLR2 induced activation of Ser-727 STAT1 phosphorylation required the adapter protein MyD88, whereas TLR4 induced activation of Ser-727 STAT1 phosphorylation was not solely dependent on MyD88 ... Lastly, TLR4 induced activation of Ser-727 STAT1 phosphorylation could be blocked by rottlerin, a specific inhibitor of protein kinase C-delta
Alvarez et al., J Immunol 2003 : TLR2 stimulation of RAW264.7 cells increased both STAT1beta protein and mRNA expression, suggesting that the increased STAT1beta phosphorylation results from increased STAT1beta expression ... These findings suggest that M. avium infection of mouse macrophages inhibits IFN-gamma signaling through a TLR2 dependent increase in STAT1beta expression by mRNA stablization and a TLR2 independent inhibition of STAT1 tyrosine phosphorylation
Shoenfelt et al., J Endotoxin Res 2006 : Previous studies demonstrated that TLR2 and TLR4 engagement leads to rapid phosphorylation of the transcription factor STAT1 at serine 727 ( Ser-727 STAT1 ) in murine macrophages ... Unlike other cell types, the p38 mitogen activated protein kinase was necessary, but not sufficient, for TLR induced phosphorylation of Ser-727 STAT1 in macrophages
Rothlin et al., Cell 2007 (Inflammation) : TLR induction of IFNAR-STAT1 signaling upregulates the TAM system, which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3
Tel et al., Cancer Immunol Immunother 2012 : Furthermore, oxaliplatin decreased TLR induced STAT1 and STAT3 expression, and NF-?B mediated responses