Cheng et al., Chem Biol 2012
(MAP Kinase Signaling System) :
We found that indirubin derivative E738 inhibited both TGFß and BMP pathways through ubiquitin-proteasome mediated depletion of total R-Smad pools, although phospho-R-Smad levels were initially stabilized by GSK3ß and cyclin dependent kinase inhibition
Wakasugi et al., J Clin Pathol 1997
(Breast Neoplasms...) :
On the other hand p21/Cip1 , a Cdk2 inhibitor , was expressed in 18 of 25 tumours with underphosphorylated pRB, while four of the five tumours with hyperphosphorylated pRB showed no expression of p21/Cip1