Gene interactions and pathways from curated databases and text-mining

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CREB5 — EDN1

Text-mined interactions from Literome

Tada et al., J Invest Dermatol 2002 : The concomitant presence of endothelin-1 , basic fibroblast growth factor, and alpha-melanotropin significantly potentiated CREB phosphorylation
Egan et al., Cell Signal 2004 : This study has examined the intracellular regulation of CREB by endothelin-1 (ET-1) and depolarization in native VSM, comparing proliferative and fully differentiated phenotypes
Nakajima et al., Arch Dermatol Res 2011 (Melanoma) : Signaling analysis with specific inhibitors and immunoblots revealed that in melanoma cells treated with the extract, there was a marked deficiency in the EDN1 stimulated phosphorylation of Raf-1, MEK, ERK, MITF and CREB