Gene interactions and pathways from curated databases and text-mining

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BRCA1 — NBN

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Paull et al., Proc Natl Acad Sci U S A 2001 : As a result of this binding, Brca1 inhibits the nucleolytic activities of the Mre11/Rad50/Nbs1 complex , an enzyme implicated in numerous aspects of double-strand break repair
Yang et al., PloS one 2008 (Adenocarcinoma...) : Oncogenic K-ras induced BASC accumulation and tumor growth were blocked by treatment with a small molecule PI3K inhibitor and enhanced by inactivation of phosphatase and tensin homologue deleted from chromosome 10, a negative regulator of PI3K
Dovey et al., Proc Natl Acad Sci U S A 2008 (Cell Transformation, Neoplastic...) : Abrogated lung cancer development and BASC self-renewal occur partially in a p19(ARF) dependent manner
Antoccia et al., Radiat Res 2008 (Chromosome Aberrations...) : It is noted that BRCA1 is required for the interaction of NBS1 with SMC1, whereas the reverse is not the case, since BRCA1 is able to bind to NBS1 in the absence of an NBS1/SMC1 interaction as observed in MRE11- or RAD50-deficient cells ... Our results reveal that ATM plays a fundamental role in promoting the radiation induced interaction of NBS1 with SMC1 in the presence of BRCA1 , leading to the maintenance of chromosomal integrity