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CD14 — IL10

Text-mined interactions from Literome

van Furth et al., Infect Immun 1999 : The objective of the present study was to investigate whether the production of tumor necrosis factor alpha (TNF) and interleukin-10 (IL-10) by human monocytes stimulated by intact heat killed or live Haemophilus influenzae or Streptococcus pneumoniae is mediated by CD14
Iwagaki et al., Infect Immun 2000 : The purpose of this study was to compare and contrast the endotoxin neutralizing activities of two synthetic antiendotoxin peptides ( SAEP-2 and SAEP-4 ), PMB, and an LPS core-specific monoclonal antibody ( MAb ), WN1 222-5, based on their abilities to inhibit CD14 mediated target cell uptake of fluorescein isothiocyanate ( FITC ) -conjugated LPS, detected by flow cytometry and confocal microscopy, and LPS induced production of the proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), as measured by bioassays
Creery et al., Clin Diagn Lab Immunol 2002 : In contrast, dexamethasone inhibited IL-10 dependent LPS induced CD14 expression by interfering with IL-10 induced signals but not by blocking IL-10 production
Li et al., Biochem Biophys Res Commun 2004 : We show here that IL-10 in the presence of M-CSF and IL-4 triggers the generation of CD14 ( + ) CD16 ( ++ ) cells from highly purified human cord blood ( CB ) and adult blood Mo. CB Mo were more sensitive to this cytokine combination than adult Mo. IL-10 induced CD14 ( + ) CD16 ( ++ ) cells that expressed dendritic cell markers : CD80, CD86, HLA-DR, and CD83 and initiated significantly decreased allogeneic mixed lymphocyte reactions ( MLRs )
Ji et al., Int Immunol 2005 (HIV Infections) : In addition, soluble HIV-1 gp160 could induce CD14 ( + ) monocytes to produce IL-10 but at lower levels ... Taken together, HIV-1 binding to CD14 ( + ) monocytes can induce CD4 independent IL-10 production at both mRNA and protein levels
Rahimi et al., J Immunol 2005 : STAT-1 mediates the stimulatory effect of IL-10 on CD14 expression in human monocytic cells ... Our results show that LPS induced CD14 expression on monocytic cells may be mediated by endogenously produced IL-10 ... To investigate the molecular mechanism by which IL-10 enhances CD14 expression, both human monocytes and the promyelocytic HL-60 cells were used as model systems ... Finally, STAT-1 interfering RNA inhibited IL-10 induced CD14 expression ... Taken together, these results suggest that IL-10 induced CD14 up-regulation in human monocytic cells may be mediated by STAT-1 activation through the activation of PI3K either alone or in concert with the ERK MAPK
Sandanger et al., J Immunol 2009 (HIV Infections) : IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV infected patients ... Using ELISA, we demonstrated that IL-10 had a profound dose- and time related effect on the release of soluble MD-2 and soluble CD14 from monocytes
Thorgersen et al., FASEB J 2010 (Sepsis) : The proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8, but not the anti-inflammatory cytokine IL-10 , were efficiently inhibited by anti-CD14
Chávez-Sánchez et al., Lipids in health and disease 2010 : The activation of CD14 , TLR4, and TLR2 by mmLDL induces IL-1ß, IL-6, and IL-10 secretion in human monocytes and macrophages ... Blocking CD14 in monocytes inhibited secretion of interleukin (IL)-1ß ( 72 % ), IL-6 ( 58 % ) and IL-10 ( 63 % ), and blocking TLR4 inhibited secretion of IL-1ß by 67 %, IL-6 by 63 % and IL-10 by 60 %
Sun et al., Curr Mol Med 2012 (Chronic Disease...) : However, in the presence of IL-4 or IL10 , CD14 ( + ) CD16 ( - ) monocytes of HIV infected patients produced more TNF-a, IL-6, IL-12 or Il-1ß after IFN-?/LPS stimulation than the healthy control, supporting the impaired IL-4R and IL-10R signal pathways in patients with LTNP and CHI. Therefore, our present study offered the basic information for the Th1/Th2 cytokine receptor expression and function on monocyte subsets in untreated HIV infected individuals
Bagchi et al., Cytokine 2013 : IL-10 caused a significant increase in the expression of CD14 , MyD88 and TLR4
Ziegler-Heitbrock et al., Eur J Immunol 1994 : This CD14 molecule was functional in that lipopolysaccharide stimulation induced interleukin (IL)-6 and IL-10 in clones 1 and 2 but not in clone 3
Spittler et al., Immunology 1995 : IL-10 modestly triggered CD14 antigen expression on monocytes but not U937
Möttönen et al., Br J Rheumatol 1998 (Arthritis, Rheumatoid) : IL-10 reduced the expression of CD40, CD86 and HLA-DR, and increased the expression of CD14 , on SF macrophages