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EPHB2 — PHKA2
Text-mined interactions from Literome
Blaukat et al., J Biol Chem 1999
:
Expression of a Grb2 mutant with a deletion of the amino-terminal Src homology 3 domain or the carboxyl-terminal tail of Sos strongly reduced
Pyk2 induced
ERK activation, with no apparent effect on JNK activity ... Grb2 with a deleted carboxyl-terminal Src homology 3 domain partially blocked
Pyk2 induced
ERK and JNK pathways, whereas expression of dominant interfering mutants of p130Cas or Crk specifically inhibited JNK but not ERK activation by Pyk2
Tahara et al., J Am Coll Cardiol 2001
(Arrhythmias, Cardiac) :
These findings indicate that KBs induce
ERK activation, which starts with Ca ( 2+ ) entry through the L-type Ca ( 2+ ) channel in cardiomyocytes, and that EGFR and
Pyk2 are
involved in this activation
Shah et al., Mol Pharmacol 2002
:
Agonist activation of endogenous angiotensin II (Ang II) AT(1) receptors expressed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the proline-rich tyrosine kinase
PyK-2 , and
ERK activation ... Ang II-induced
ERK activation in C9 cells is initiated by a PKCdelta dependent but Ca ( 2+ ) -independent mechanism and is
mediated by the
Src/Pyk2 complex through trans-activation of the EGF-R
Kodama et al., J Mol Cell Cardiol 2002
(MAP Kinase Signaling System) :
Role of EGF Receptor and
Pyk2 in endothelin-1 induced
ERK activation in rat cardiomyocytes
Chen et al., J Biol Chem 2002
:
Similarly, in L6 myotubes, ( a ) AICAR activated PYK2, ERK, PLD, and aPKCs ; ( b ) effects of AICAR on
ERK were
inhibited by genistein, PD98059, and expression of dominant negative
PYK2 ; ( c ) effects of AICAR on PLD were inhibited by MEK1 inhibitor UO126 ; ( d ) effects of AICAR on aPKCs were inhibited by genistein, PD98059, 1-butanol, and expression of dominant negative forms of PYK2, GRB2, SOS, RAS, RAF, and ERK; and (e) effects of AICAR on 2DOG uptake/GLUT4 translocation were inhibited by genistein, PD98059, UO126, 1-butanol, cell-permeable myristoylated PKC-zeta pseudosubstrate, and expression of kinase-inactive RAF, ERK, and PKC-zeta
Shah et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
The Src inhibitor, PP2, the C-terminal Src kinase (Csk), and dominant negative
Pyk2 attenuated
ERK1/2 activation by GnRH and PMA but not by EGF
Farshori et al., J Steroid Biochem Mol Biol 2003
:
Dominant negative
Pyk2 ( PKM )
had no effect on GnRH induced
ERK1/2 phosphorylation and c-fos expression
Daou et al., Free Radic Biol Med 2004
:
Our aim was to investigate the involvement of ROS in ET-1 mediated activation of ERK1/2, PKB, and
Pyk2 in A-10 VSMCs. ET-1
stimulated ERK1/2 , PKB, and Pyk2 phosphorylation in a dose- and time dependent manner
Xie et al., Mol Endocrinol 2008
:
Knockdown of Pyk2 using specific small interfering RNAs revealed that
Pyk2 contributed to modulation of GnRH induced
ERK but not c-Jun N-terminal kinase activation
Schauwienold et al., J Biol Chem 2008
:
In vascular smooth muscle cells, both matrix-metalloproteinase dependent extracellular shedding of membrane bound epidermal growth factor (EGF) receptor ligands and activation of the nonreceptor tyrosine kinases
Pyk2 and Src
contributed to the thrombin induced
ERK1/2 phosphorylation
Eisinger et al., Cell Signal 2008
:
Integrin dependent
ERK1/2 activation does not
involve FAK/Pyk-2 , because over-expression of the FAK/Pyk-2 inhibitor SOCS-3 failed to attenuate DOR signaling
Nicodemo et al., Molecular brain 2010
:
Treatments that prevent Pyk2 phosphorylation in cortical neurons, and the overexpression of
Pyk2 dominant negative and catalytically inactive Pyk2 mutants in HEK293 cells,
prevent ERK1/2 phosphorylation ... The
Pyk2 mediated
activation of
ERK1/2 phosphorylation is also Src-, calmodulin- and protein kinase C-dependent
Fisher et al., American journal of physiology. Renal physiology 2012
(MAP Kinase Signaling System) :
To examine specificity of kinase activation and its effects, we used Pyk2 small interfering RNA to knockdown Pyk2 expression levels, the Src kinase inhibitor 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] -pyrimidine ( PP 1 ) to
inhibit Pyk2 phosphorylation, and the MEK inhibitor U0126 to inhibit
ERK1/2 phosphorylation
Murasawa et al., Hypertension 1998
:
Role of calcium-sensitive tyrosine kinase
Pyk2/CAKbeta/RAFTK in angiotensin II
induced Ras/ERK signaling