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CAT — NFKB1
Text-mined interactions from Literome
Wang et al., Ann Clin Lab Sci 1999
:
Superoxide dismutase ( SOD ), but not
catalase or sodium formate,
inhibited this
NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction
Ye et al., Ann Clin Lab Sci 2000
:
Exogenous superoxide dismutase ( SOD )
enhanced the
NF-kappaB activation by PMA, while
catalase blocked it
Ghassemi et al., AIDS Res Hum Retroviruses 2000
:
In addition, transient transfection of U937 cells with full-length wild-type as well as NF-kappaB binding site deleted mutant HIV-1 LTR-CAT constructs revealed that MAC induced HIV-LTR
CAT is
NF-kappaB dependent
Kang et al., J Toxicol Environ Health 2000
:
Further evidence for the involvement of ROS in NF-kappaB activation is that 1 mM H2O2 enhanced
NF-kappaB/DNA binding and that this activation was
inhibited by
catalase
Jaspers et al., Am J Respir Cell Mol Biol 2000
(MAP Kinase Signaling System) :
Both nuclear translocation of
NF-kappaB and enhanced kappaB dependent transcription induced by V ( IV ) were
inhibited by overexpression of
catalase , but not Cu, Zn superoxide dismutase ( Cu, Zn-SOD ), indicating that peroxides rather than superoxides initiated signaling
Murley et al., Free Radic Biol Med 2001
:
Neither
catalase nor pyruvate when added to the culture medium to minimize hydrogen peroxide production
had an effect on
NFkappaB activation by SH
Weber et al., Chem Res Toxicol 2001
:
Catalase fully
inhibited peak TGHQ mediated TRE- and
NF-kappaB binding activity
Kitaura et al., FEMS Immunol Med Microbiol 2001
(HIV Infections...) :
These findings indicated that activation of Mycobacterium induced LTR
CAT is
NF-kappaB dependent
Fan et al., J Biol Chem 2003
(Anoxia) :
Overexpression of glutathione peroxidase-1 or
catalase , but not Mn-SOD or Cu, Zn-SOD, significantly
reduced both
NF kappa B activation and tyrosine phosphorylation of I kappa B alpha
Kontou et al., Biol Chem 2003
(Chromosomal Instability...) :
Cotransfection of the
NF-kappaB dependent
CAT plasmid with the Trx/nuc-plasmid into FA fibroblasts increased the CAT expression to almost that of control cells, indicating that in this model system with diminished thioredoxin content NF-kappaB requires thioredoxin for binding to its specific promotor
Jang et al., Biochem Biophys Res Commun 2004
:
Catalase also
induced activation of
NF-kappaB , PI3K, ERKs, p38s, or JNKs. Catalase induced COX-2 expression was abrogated by treatment of MG-132 ( a NF-kappaB inhibitor ) or LY294002 ( a PI3K inhibitor ), but not by treatment of PD98059 ( an ERK inhibitor ), SB203580 ( a p38 inhibitor ), or SP600125 ( a JNK inhibitor )
Pawate et al., J Neurosci Res 2004
(Encephalitis...) :
Phox inhibitors and
catalase also suppressed LPS/IFNgamma induced expression of cytokines, i.e., interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)alpha and
blocked LPS activation of MAP kinases ( i.e., p38 MAPK, c-Jun N-terminal kinase and extracellular signal regulated kinase ),
NFkappaB , and IFNgamma induced STAT1 phosphorylation
Jang et al., Biochem Pharmacol 2004
:
Catalase induces the expression of inducible nitric oxide synthase through activation of
NF-kappaB and PI3K signaling pathway in Raw 264.7 cells
Jang et al., Cell Signal 2005
:
Interestingly, there was PI3K dependent activation of AKT, p70S6K, JNKs, and
NF-kappaB in
response to
catalase
Lee et al., J Cell Physiol 2008
:
Catalase inhibited the effect of H2O2 on MAPKs and
NF-kappaB
Shan et al., J Biomed Biotechnol 2009
(Brain Injuries...) :
Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2),
inhibited nuclear translocation of
nuclear factor-kappaB (NF-kappaB) , increased the activity of copper/zinc superoxide dismutase ( Cu/Zn-SOD ) and
catalase (CAT) , and reduced the content of malondialdehyde ( MDA ), respectively
Libermann et al., Mol Cell Biol 1990
:
However, stimulation of U-937 and HeLa cells by inducers of
NF-kappa B led to a dramatic increase in
CAT activity
Das et al., Am J Physiol 1995
:
SOD and
catalase ( 500 U/ml ) plus ethanol ( 1 mM ) did not
inhibit activation of
NF-kappa B or elevation of steady-state MnSOD mRNA levels by NAC, DTT, or 2-ME
Yao et al., Environ Health Perspect 1995
:
Linker scanning mutational analysis of transcription factor binding sites in the promoter revealed that both the
NF kappa B and an adjacent aromatic hydrocarbon response element ( AhRE ) are
required for TCDD dependent
CAT expression
Suzuki et al., Biochem Biophys Res Commun 1995
:
Transient overexpression of
catalase does not
inhibit TNF- or PMA induced
NF-kappa B activation ... Overexpression of
catalase , however, did not
block TNF- or PMA induced
NF-kappa B activation
Ginn-Pease et al., Biochem Biophys Res Commun 1996
:
However, signals induced by oxidative conditions effectively cooperated with stimulatory signals provided by PMA but not with T cell receptor/CD3 stimulation to induce significant increases in
NF kappa B CAT responses
Schmidt et al., Chem Biol 1995
(Second Messenger Systems) :
The
catalase inhibitor aminotriazol
restored NF-kappa B induction
Chen et al., Ann Clin Lab Sci 1998
:
Catalase , metal chelator, deferoxamine, and the silanol group ( SiOH ) blocker, poly ( 2-vinylpyridine-N-oxide ) ( PVPNO ), also
inhibited silica induced
NF-kappa B activation
Natarajan et al., Arch Biochem Biophys 1998
:
The
NF-kappaB dependent
CAT reporter gene expression in transient transfection assays was also suppressed by the PTK inhibitors
Lentsch et al., Am J Pathol 1998
(Alveolitis, Extrinsic Allergic...) :
N-acetylcysteine, but not
catalase ,
suppressed activation of lung
NF-kappaB
Nilakantan et al., Carcinogenesis 1998
:
Liver-specific
catalase expression in transgenic mice
inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate ... Ciprofibrate increased the activation of
nuclear factor (NF)-kappaB in non-transgenic mice, but this increase was
inhibited by
catalase overexpression
Chen et al., Biochem Pharmacol 1998
:
The increase in expression of mRNA for COX-2 induced by catalase may be related to the ability of
catalase to
stimulate cyclic AMP response element ( CRE ) and NF-IL6 transcription factors, but not
nuclear factor kappa B (NF-kappaB) , for electrophoretic mobility shift assays ( EMSA ) showed that catalase enhanced nuclear factor binding to cyclic AMP response element and NF-IL6 but not to NF-kappaB
Vollebregt et al., FEBS Lett 1998
:
The neutrophil NADPH oxidase inhibitor diphenylene iodonium,
catalase , and other oxidant scavengers did not
inhibit NF-kappaB activation, and no activation was seen with added hydrogen peroxide