Zahner et al., J Biol Chem 2002
:
These data suggest that COX-2 inhibits mesangial cell proliferation by a novel mechanism that is independent of prostaglandin synthesis, but involves p53, p21 ( cip-1 ), and p27 ( kip-1 )
Mäkitie et al., J Otolaryngol 2003
(Carcinoma, Squamous Cell...) :
Selective inhibition of cyclooxygenase 2 induces p27kip1 and skp2 in oral squamous cell carcinoma
Lee et al., Head Neck 2004
(Carcinoma, Squamous Cell...) :
Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head and neck squamous cell carcinoma cell lines ... Overexpression of p53 markedly downregulated the transcription of COX-2, but the overexpression of p27 did not affect COX-2 levels in HNSCC cell lines