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IFNG — KIR2DL4
Text-mined interactions from Literome
Rajagopalan et al., J Immunol 2001
:
The
induction by
KIR2DL4 of
IFN-gamma production by resting NK cells was blocked by an inhibitor of the p38 mitogen activated protein kinase signaling pathway, in contrast to the IL-2 induced IFN-gamma secretion that was sensitive to inhibition of the extracellular signal regulated kinase mitogen activated protein kinase pathway
Kikuchi-Maki et al., J Immunol 2005
:
KIR2DL4 ( 2DL4, CD158d ), a member of the human killer cell Ig-like receptor (KIR) family,
triggers potent
IFN-gamma responses but weak cytotoxicity in resting NK cells
Goodridge et al., Mol Hum Reprod 2009
:
In this study, we assessed KIR2DL4 expression and
IFNgamma secretion as a
result of
KIR2DL4 ligation, by decidual NK ( dNK ) cells ... Although freshly isolated dNK did not secrete IFNgamma in response to KIR2DL4 ligation regardless of KIR2DL4 genotype, activation by in vitro culture with IL-2 enabled dNK cells from individuals with at least one 10A allele, but not those without a 10A allele, to secrete
IFNgamma in
response to
KIR2DL4 ligation