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CDC25A — IFI27

Text-mined interactions from Literome

Chiu et al., Anticancer Res 2009 (Carcinoma, Squamous Cell...) : Treatment with 30 microM of aloe-emodin led to S-phase arrest through promoted p53, p21 and p27 , but inhibited cyclin A, E, thymidylate synthase and Cdc25A levels
Lee et al., Invest Ophthalmol Vis Sci 2011 : Cdc25A inhibitor blocked activation of Cdk2, phosphorylation of p27 at Thr187, and cell proliferation
Lee et al., Invest Ophthalmol Vis Sci 2011 : However, the downstream mechanism involved in cell cycle progression in hCECs is identical to that of rCECs : phosphorylation of p27 at Ser10 was mediated by kinase interacting stathmin ( KIS ), confirmed with siRNA to KIS, and phosphorylation of p27 at Thr187 was mediated by cell division cycle 25A (Cdc25A) , confirmed using Cdc25A inhibitor
Alevizopoulos et al., EMBO J 1997 : We suggest that this effect of Myc is mediated by its action upstream of cyclin E-CDK2, and occurs via the neutralization of p27 ( Kip1 ) family proteins, rather than induction of Cdc25A