◀ Back to PIK3CA
PIK3CA — PIK3CB
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes phosphatidylinositol 3-kinase complex:
phosphatidylinositol 3-kinase complex complex (PIK3CA-PIK3CB-PIK3CD-PIK3CG-PIK3C2G-PIK3R2-PIK3R3)
Vanhaesebroeck et al., Proc Natl Acad Sci U S A 1997, Chantry et al., J Biol Chem 1997
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IRef Intact Interaction:
Complex of 81 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
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IRef Intact Interaction:
Complex of PIK3CB-PIK3R3-PIK3CA
(association, anti bait coimmunoprecipitation)
Beauséjour et al., Apoptosis 2012
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IRef Intact Interaction:
Complex of 43 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
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IRef Intact Interaction:
Complex of PIK3R2-PIK3CA-PIK3CB
(association, anti bait coimmunoprecipitation)
Beauséjour et al., Apoptosis 2012
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IRef Intact Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
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IRef Intact Interaction:
Complex of 20 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
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IRef Intact Interaction:
Complex of 111 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
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IRef Intact Interaction:
Complex of 29 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
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IRef Intact Interaction:
Complex of 40 proteins
(association, tandem affinity purification)
Li et al., Molecular systems biology 2013
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IRef Intact Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
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IRef Intact Interaction:
Complex of 12 proteins
(association, tandem affinity purification)
Brehme et al., Proc Natl Acad Sci U S A 2009
Text-mined interactions from Literome
Windmiller et al., J Biol Chem 2003
:
These data demonstrate : ( a ) a calcium independent role for
p110alpha in antigen stimulated degranulation ; ( b ) a
requirement for
p110beta in adenosine receptor signaling ; and ( c ) a requirement for hVPS34 during M1 muscarinic receptor signaling
Komori et al., Clinical calcium 2006
:
Phosphoinositide 3-kinase
(PI3K)-Akt signaling enhances DNA binding of Runx2 and Runx2 dependent transcription, and Runx2
upregulates PI3K subunits ( p85 and
p110 beta ) and Akt
Wang et al., Biochem J 2007
:
In the present study we have demonstrated that : ( i ) PAR-2 increases
p110alpha- and p110beta associated lipid kinase activities, and both p110alpha and
p110beta are
inhibited by over-expression of either beta-arrestin-1 or -2 ; ( ii ) both beta-arrestin-1 and -2 directly inhibit the p110alpha catalytic subunit in vitro, whereas only beta-arrestin-2 directly inhibited p110beta ; ( iii ) examination of upstream pathways revealed that PAR-2 induced PI3K activity required the small GTPase Cdc ( cell-division cycle)42, but not tyrosine phosphorylation of p85 ; and ( iv ) beta-arrestins inhibit PAR-2 induced Cdc42 activation
Ciraolo et al., Science signaling 2008
(Cell Transformation, Neoplastic...) :
Pharmacological and genetic analyses of p110beta function revealed that
p110beta catalytic activity is
required for
PI3K signaling downstream of heterotrimeric guanine nucleotide binding protein ( G protein ) -coupled receptors as well as to sustain long-term insulin signaling
Billottet et al., Cancer Res 2009
(Leukemia, Promyelocytic, Acute) :
In summary, class I
PI3K signaling,
mediated by
p110beta and p110delta, plays an important role in basal and ATRA induced cell survival mechanisms in APL
Jiang et al., J Biol Chem 2010
(Prostatic Neoplasms) :
Basal
PI3K activity was
mediated by p110beta in PC3 cells and by both
p110beta and p110delta in LNCaP cells, whereas p110alpha was required for PI3K activation in response to RTK stimulation by heregulin-beta1 ... These findings show that basal
PI3K activity in PTEN-deficient PCa cells is RTK independent and can be
mediated by
p110beta and p110delta ... Increased
p110beta expression in PCa may be
required for RTK independent
PI3K pathway activation in adult prostate epithelium with genetic or epigenetic PTEN down-regulation