Dai et al., Biochem Biophys Res Commun 2002
:
SGKL is activated via its lipid binding domain ( phox homology domain ) in response to PI3K signaling
Tessier et al., J Biol Chem 2006
:
Both a functional PX domain and PI3K activation are necessary for phosphorylation of SGK3 at two regulatory sites ( Thr-320 and Ser-486 ) and subsequent induction of kinase activity
Liu et al., Hepatology 2012
(Carcinoma, Hepatocellular...) :
We also found that expression of SGK3 , which like AKT is activated by PI3K/PDK1 signaling, has more significance than overexpression of AKT in predicting poor outcome in HCC patients