Wengenack et al., Brain Res 2004
(Amyotrophic Lateral Sclerosis...) :
A novel, MN-specific, Fas mediated programmed cell death (PCD) pathway has been reported in MNs which involves the activation of p38 MAP kinase ( phospho-p38 ) and neuronal nitric oxide synthase (nNOS) Martin et al., J Neurosci 2005
(Amyotrophic Lateral Sclerosis...) :
After injury, MNs increased nNOS protein but decreased iNOS protein ; however, iNOS contributed more than nNOS to basal and injury induced levels of NADPH diaphorase activity in MNs