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RELA — S100A12
Text-mined interactions from Literome
Millet et al., J Biol Chem 2000
:
CGRP inhibits the accumulation of
NF-kappaB complexes in the nucleus by preventing phosphorylation and degradation of the NF-kappaB inhibitor IkappaB
Hou et al., J Neurosci Res 2003
:
The inhibitors of PKC, JNK MAPK and
NF-kappaB , but not p38 or ERK1/2 MAPK,
blocked IL-1beta induced
CGRP release
Li et al., Am J Physiol Cell Physiol 2006
:
Subsequent investigation revealed that
CGRP inhibited IL-1beta evoked
NF-kappaB activity by suppressing IkappaBalpha phosphorylation and degradation ... We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3',5'-cyclic monophosphothioate and the Sp isomer of adenosine 3',5'-cyclic monophosphothioate, mimicked the
CGRP suppressive
effect on IL-1beta induced ROS formation,
NF-kappaB activation, and MCP-1 secretion
Srikrishna et al., J Cell Biochem 2010
:
mAbGB3.1, an antibody against carboxylated glycans, blocks
S100A12 mediated
NF-kappaB signaling in HeLa cells expressing full-length RAGE
McGillis et al., Can J Physiol Pharmacol 1995
:
To determine whether the inhibitory effects of
CGRP on sIg expression are
mediated by an inhibition of
NF kappa-B translocation to the nucleus, electrophoretic mobility shift assays were performed using nuclear proteins from 70Z/3 cells ... There was no difference in NF kappa-B binding activity in cells that had been treated with LPS or LPS + CGRP, suggesting that the inhibitory effect of
CGRP is not
mediated by an inhibition of
NF kappa-B activity