Gene interactions and pathways from curated databases and text-mining

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ICAM3 — RELA

Text-mined interactions from Literome

Brand et al., Gastroenterology 1999 : Stimulation of ICAM expression is mediated by activation of the transcription factor NF-kappaB
Li et al., J Immunol 2003 : In surviving cells, TRAIL activates NF-kappaB , induces expression of E-selectin, ICAM-1 , and IL-8, and promotes adhesion of leukocytes
Mullan et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid...) : A-SAA induced expression of VCAM-1, ICAM-1 , and MMP-1 was down-regulated by NF-kappaB inhibition
Reed et al., Dig Dis Sci 2005 (Colitis...) : Colon tissue was collected for assessment of histological changes, NF-kappa B activation , myeloperoxidase (MPO) activity, and expression of NK-1R, SP, TNFalpha, IL-1beta, VCAM-1, ICAM-1 , E-selectin, CINC-1, MIP-1alpha, and iNOS
Bolick et al., Arterioscler Thromb Vasc Biol 2006 : Inhibition of rhoA and PKCalpha significantly reduced NF-kappaB activation, ICAM-1 induction , and monocyte adhesion to aorta
Yi et al., Inflamm Res 2006 (Endotoxemia...) : Lung injury score, lung wet-to-dry weight ( W/D ) ratio, percentage of neutrophils ( PMNs ) in BALF, lung permeability index (LPI), intercellular adhesion molecule-1 ( ICAM-1 ) expression and activation of nuclear factor-kappa B (NF-kappaB) in the lungs were determined
Crispen et al., Prostate 2007 (Neoplasm Invasiveness...) : Treatment with alpha-tocopherol succinate ( VES ) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen independent PC-3, DU-145, and CA-HPV-10 cells
Ishizuka et al., J Pharmacol Exp Ther 2008 : Inhibition of NF-kappaB activation and inhibition of ERK1/2 phosphorylation inhibited 20-HETE induced ICAM expression
Cepinskas et al., Am J Physiol Gastrointest Liver Physiol 2008 (Disease Models, Animal...) : Induction of CLP resulted in increased PMN accumulation, ICAM-1 expression, and activation of NF-kappaB in the liver of septic mice
Soares et al., J Immunol 1998 : We report here that adenovirus mediated expression of a dominant negative C-terminal truncation mutant of p65/RelA ( p65RHD ) inhibits the induction of proinflammatory genes, such as E-selectin, ICAM-1 , VCAM-1, IL-8, and inducible nitric oxide synthase, in EC as efficiently as does I kappaB alpha