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CXCL12 — IL8
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Lin et al., Int Arch Allergy Immunol 2001
:
SDF-1 induces
IL-8 production and transendothelial migration of human cord blood derived mast cells ... Human mast cells can both migrate across vascular endothelium and produce the pro-angiogenic chemokine
IL-8 in
response to
SDF-1
Nanki et al., J Immunol 2001
(Arthritis, Rheumatoid) :
In this study we show that CCL2/monocyte chemotactic protein-1, CCL5/RANTES, and
CXCL12/stromal cell derived factor-1
enhanced IL-6 and
IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Damås et al., Circulation 2002
(Angina, Unstable) :
In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1,
interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina ... In vitro,
SDF-1alpha ( 500 ng/mL )
reduced both unstimulated and endotoxin/mitogen stimulated mRNA and protein levels of monocyte chemoattractant protein-1,
interleukin-8 , matrix metalloproteinase-9, and tissue factor while increasing tissue inhibitor of metalloproteinases-1 in PBMC from patients with unstable angina
Ping et al., J Neurooncol 2007
(Brain Neoplasms...) :
We found that Nordy potently inhibited CXCR4 ligand
SDF-1 induced production of
IL-8 and vascular endothelial cell growth factor, two important angiogenic factors implicated in the progression of malignant tumors
Scupoli et al., Haematologica 2008
(Leukemia-Lymphoma, Adult T-Cell) :
We showed that
CXCL12 activates the nuclear factor-kappaB and JNK/AP-1 pathways, and that these events are
required for increased expression of
interleukin-8 ... Furthermore, the nuclear factor-kappaB and AP-1 elements of the interleukin-8 promoter are necessary for both constitutive and
CXCL12 induced
interleukin-8 expression
Picinich et al., Exp Cell Res 2010
:
In this report, we demonstrate that
interleukin 8 (IL-8) induces an increase in
SDF-1 expression by MSCs ... The increase in
SDF-1 expression in
response to
IL-8 is mediated by the activation of the protein kinase C (PKC) zeta isoform ... These results indicate that
IL-8 mediated
SDF-1 production by MSCs requires PKC zeta activation
Lai et al., Int J Gynecol Cancer 2011
(Genital Neoplasms, Female...) :
Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2,
CXCL2 , IL-6, and IL-8, and in SKOV3 cells, mRNA levels of CCL2, CCL20, CXCL1, CXCL2, IL-6, and
IL-8 increased
Li et al., Oral Oncol 2012
(Carcinoma, Squamous Cell...) :
The angiogenesis profiling from angiogenesis array and reverse transcription polymerase chain reaction indicates that
IL-8 can be significantly
triggered by
SDF-1/CXCR4 interaction in LHSCCs
Lee et al., Eur Respir J 2012
(Inflammation...) :
NRF knockdown
enhanced IL-8/CXCL8 production in normal PBMCs, whilst NRF overexpression attenuated
IL-8/CXCL8 production