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AKT1 — PLK1
Text-mined interactions from Literome
Shtivelman et al., Mol Cancer Res 2003
:
The checkpoint protein CHFR implicated in degradation of Plk1 is involved in the
regulation of
Plk1 by
PKB ... Expression of a mutant form of CHFR that can not be phosphorylated by
PKB results in reduction of levels of
Plk1 and inhibition of mitotic entry under normal conditions and after DNA damage ... The deregulated activation of
PKB that occurs frequently in tumors might inhibit CHFR activity after DNA damage and therefore
promote Plk1 accumulation leading to the disruption of the DNA damage checkpoint
Leonard et al., Cell cycle (Georgetown, Tex.) 2013
:
In primary keratinocytes, knockdown of PTEN increased whole-cell levels of ?-tubulin and
PLK-1 in an
Akt dependent manner and had little effect on recruitment of either protein to mitotic centrosomes ... Inhibition of
Akt activation with MK2206
reduced the whole-cell and
centrosome levels of PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes ... Inhibition of
Akt activation with MK2206
reduced the whole-cell and centrosome levels of
PLK-1 and ?-tubulin and also prevented the recruitment of PTEN to mitotic centrosomes
Kasahara et al., Nature communications 2013
:
Inhibition of phosphatidylinositol 3-kinase (PI3K) and
Akt significantly
reduces the level of
Plk1-Ser99 phosphorylation and delays metaphase to anaphase transition ...
Plk1-Ser99 phosphorylation
requires not only
Akt activity but also protein ( s ) associated with Plk1 in a mitosis-specific manner