Gene interactions and pathways from curated databases and text-mining

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ANG — CCL2

Text-mined interactions from Literome

Ortego et al., Atherosclerosis 1999 (Coronary Artery Disease...) : Ang II and TNF-alpha induced the expression of IP-10 ( 1.5 and 3.4-fold ) and MCP-1 ( 2.4 and 4-fold ) in VSMC
Satonaka et al., Circ Res 2004 (Calcium Signaling...) : Angiotensin II (Ang II) also significantly stimulated MCP-1 expression, and this increase was significantly inhibited by cyclosporin A ( CyA )
Yamagishi et al., Cell Tissue Res 2005 : Ang II significantly induced redox-sensitive transcriptional factor NF-kappaB activation and subsequent monocyte chemoattractant protein-1 expression in human umbilical vein ECs ( HUVEC ), both of which were completely inhibited by PEDF or the anti-oxidant N-acetylcysteine
Kanno et al., Dig Dis Sci 2005 (Hepatitis...) : These results suggest that Ang II modulates hepatic inflammation via production of MCP-1 by hepatic stellate cells, and the effect of Ang II on MCP-1 production is, at least partly, mediated by the Rho/Rho-kinase pathway
Wu et al., J Hypertens 2006 : The effect of nifedipine, a 1,4-dihydropyridine calcium antagonist, on the expression of monocyte chemoattractant protein 1 ( MCP-1 ) induced by angiotensin II (Ang II) was examined using vascular smooth muscle cells ( VSMC ) isolated from rat thoracic aorta ... Nifedipine decreased MCP-1 mRNA expression, together with NF-kappaB binding activity to the promoter region of MCP-1 induced by Ang II
Tsuchiya et al., Am J Physiol Endocrinol Metab 2006 (Obesity) : The present study was undertaken to investigate the potential mechanisms by which ANG II affects MCP-1 gene expression in rat primary cultured preadipocytes and adipose tissue in vivo
Miura et al., J Pharmacol Sci 2006 : Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II
Lee et al., Nephrol Dial Transplant 2007 (Diabetes Mellitus, Experimental...) : COMP-Ang1 suppressed both renal expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 and monocyte/macrophage infiltration in diabetic db/db mice
Ko et al., Vascul Pharmacol 2007 (Inflammation) : Among the chemokines, monocyte chemoattractant protein (MCP)-1 induced by Ang II acts as a central mediator of the inflammatory responses ... Berberine, a major component of Coptis chinensis Franch, also showed similar effects on ROS production and MCP-1 expression induced by Ang II
Guo et al., Arch Med Res 2008 (Cardiovascular Diseases) : Collectively, these results indicated that ACE2 overexpression in the THP-1 attenuates AngII induced MCP-1 production and that this reduction is likely mediated by increased Ang ( 1-7 ) level
Lee et al., Nephrol Dial Transplant 2008 (Kidney Diseases) : CsA induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA treatment were significantly reduced by COMP-Ang1
Ding et al., World journal of pediatrics : WJP 2010 : We investigated the role of c-Jun NH2-terminal kinase (JNK), a member of the mitogen activated protein kinase family, in the expression of angiotensin II (Ang II) induced monocyte chemoattractant protein-1 ( MCP-1 ) and transforming growth factor-1 ( TGF-1 ), and in the production of fibronectin ( FN ), by human mesangial cells ( HMCs )
Chen et al., Circ Res 1998 : To investigate a potential molecular basis for a link between hypertension and atherosclerosis, we studied the effects of angiotensin II (Ang II) on MCP-1 gene expression in rat aortic smooth muscle cells