Gene interactions and pathways from curated databases and text-mining

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ADORA2A — PRKAR1B

Text-mined interactions from Literome

Yao et al., Mol Pharmacol 2008 : Direct activation of PKA by adenosine-3',5'-cyclic monophosphorothioate, Sp-isomer ( Sp-cAMPS ), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC translocation to the cytosolic compartment in a process that is dependent on PLC activation and requires PKA activity
Hattori et al., Evidence-based complementary and alternative medicine : eCAM 2010 : Thus, AMP N ( 1 ) -oxide elicited neuronal differentiation of PC12 cells, as evidenced by generation of neurites, and inhibited cell growth through adenosine A(2A) receptor mediated PKA signaling, which may be responsible for characteristic actions of RJ
Lee et al., PloS one 2012 (Neurodegenerative Diseases) : In this study, we show that one cytokinin, zeatin riboside, can prevent pheochromocytoma ( PC12 ) cells from serum deprivation induced apoptosis by acting on the adenosine A(2A) receptor ( A ( 2A ) -R ), which was blocked by an A ( 2A ) -R antagonist and a protein kinase A (PKA) inhibitor, demonstrating the functional ability of zeatin riboside by mediating through A ( 2A ) -R signaling event