Gene interactions and pathways from curated databases and text-mining

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CDK8 — HRAS

Text-mined interactions from Literome

Kremerskothen et al., Neurosci Lett 2002 (Neuroblastoma) : Insulin induced expression of the activity regulated cytoskeleton associated gene ( ARC ) in human neuroblastoma cells requires p21(ras) , mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Teramoto et al., Oncogene 2003 : For example, H-Ras V12 upregulated osteopontin and Akt 1, and H-Ras and RhoA stimulated cyclin G1, cyclin dependent kinase 8, cyclin A2 and HMGI-C, while Rac1 QL and Cdc42 QL upregulated extracellular matrix and cell adhesion proteins such as alpha-actinin 4, procollagen type I and V and neuropilin