Gene interactions and pathways from curated databases and text-mining

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HRAS — NRAS

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Chiu et al., Nat Cell Biol 2002 (MAP Kinase Signaling System) : We show that oncogenic H-Ras and N-Ras engage Raf-1 on the Golgi and that endogenous Ras and unpalmitoylated H-Ras are activated in response to mitogens on the Golgi and endoplasmic reticulum ( ER ), respectively
Moon et al., Mol Cancer Res 2008 (Cell Transformation, Neoplastic) : We previously showed that H-Ras , but not N-Ras, induces MCF10A cell invasion/migration, whereas both H-Ras and N-Ras induce cell proliferation and phenotypic transformation
McKay et al., EMBO J 1986 (Cell Transformation, Neoplastic) : T15 cells have been used to demonstrate that : ( i ) a 20- to 50-fold over-expression of normal p21ras is required for complete cellular transformation, ( ii ) p21N-ras expression induces DNA synthesis and the effect can be amplified by epidermal growth factor, ( iii ) moderate increases in normal p21ras expression can influence cell behaviour
Quincoces et al., FEBS Lett 1997 : In quiescent NIH3T3 cells transfected with inducible H-ras oncogenes, the induction of H-Ras was followed 12 h later by a 3-fold increase in the mRNA expression of endogenous K-ras and N-ras ... Similarly, in NIH3T3 transfected with inducible N-ras oncogene, the induction of N-ras was followed by an increase in the expression of endogenous K- and H-ras genes