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Rigas et al., Trends Mol Med 2004
(Neoplasms) :
Mechanistically, NO-aspirin, the best studied NO-NSAID, has pleiotropic effects on cell signaling ( it inhibits Wnt signaling, induces nitric oxide synthase and NF-kappaB activation and induces cyclooxygenase-2 expression ), and this mechanistic redundancy might be central to its mode of action against cancer
Du et al., Cancer Res 2006
:
Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling
Du et al., Cancer Res 2009
(Neoplasms) :
Wnt/beta-catenin signaling regulates cytokine induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-kappaB activation in cancer cells