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FOXO1 — IGF1

Text-mined interactions from Literome

Guo et al., J Biol Chem 1999 : Reporter gene studies in HepG2 hepatoma cells show that FKHR stimulates insulin-like growth factor binding protein-1 promoter activity through an IRS, and introduction of IRSs confers this effect on a heterologous promoter
Ayalon et al., Growth Horm IGF Res 2001 (Osteosarcoma...) : In the present study the potential regulation of the IGF-I receptor (IGF-I-R) gene by PAX3-FKHR at the transcriptional level was investigated ... PAX3-FKHR was able to transactivate the IGF-I-R promoter in sarcoma derived cell lines, whereas PAX3 exhibited a reduced potency in comparison to the fusion protein
Richards et al., Mol Endocrinol 2002 : In naïve granulosa cells, both FSH and IGF-I stimulate rapid phosphorylation of FKHR at multiple sites causing its redistribution from the nucleus to the cytoplasm in a PI3K dependent manner
Li et al., Mol Cell Biochem 2002 (MAP Kinase Signaling System) : Des IGF-I increased the phosphorylation of the transcription factor FKHR in cardiac muscle only ( p < 0.05 )
Liu et al., Endocrinology 2002 : IGF-I increased the phosphorylation of glycogen synthase kinase 3beta, BAD, FKHR , and p70 ( S6 ) kinase
Kim et al., Biol Reprod 2003 : Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells
Rena et al., EMBO Rep 2004 : Our results indicate that these residues are targeted by CK1 in vivo and that the CK1 mediated phosphorylation of the MPD is required for accelerated nuclear exclusion of FOXO1a in response to IGF-1 and insulin
Schwab et al., Apoptosis 2005 (Neuroblastoma) : IGF-I induced phosphorylation of Erks ( p42/p44 ), FKHR ( FOXO1a ) ( Ser 253 ), FKHRL1 ( FOXO3a ) ( Ser 256 ), and Akt ( Ser 473 ) ... PI3-K inhibitor, LY294002, reduced IGF-I stimulated phosphorylation of FKHR , FKHRL1, and Akt, but did not affect Erk phosphorylation
Liu et al., J Endocrinol 2007 : Inhibition of phosphatidylinositol 3-kinase/Akt pathway suppressed the effect of insulin and IGF-I on FOXO1 phosphorylation
Hansen et al., PLoS Genet 2008 : Long lived daf-2 insulin/IGF-1 receptor mutants require both autophagy and the transcription factor DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16
Essaghir et al., J Biol Chem 2009 : PDGF, fibroblast growth factors ( FGF ), and IGF-I repressed the expression of FOXO genes in human fibroblasts
Srivastava et al., Int J Oncol 2009 (Cerebellar Neoplasms...) : IGF-I stimulation of serum starved cells resulted in rapid phosphorylation of Akt and FOXO1 , and was associated with a significant increase in cell viability
Cleveland et al., Am J Physiol Regul Integr Comp Physiol 2010 : IGF-I and insulin stimulated phosphorylation of FOXO1 and FOXO4 ( P < 0.05 ), which was inhibited by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor wortmannin, and decreased the abundance of polyubiquitinated proteins by 10-20 % ( P < 0.05 )
Kenyon et al., Ann N Y Acad Sci 2010 : However, the mechanisms by which inhibition of insulin/IGF-1 signaling and germline loss activate DAF-16/FOXO are distinct
Löw et al., Gen Comp Endocrinol 2011 (Nerve Degeneration) : Longevity increases when FoxO becomes activated in response to reduced insulin/IGF-1 signalling
Sengupta et al., Circ Res 2013 : In vivo, combined loss of FoxO1 and FoxO3 specifically in cardiomyocytes leads to delayed cell-cycle withdrawal and increased expression of IGF1 and FoxM1