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IL10 — TIMP1

Text-mined interactions from Literome

Lim et al., Am J Respir Crit Care Med 2000 (Pulmonary Emphysema) : IL-10 increased TIMP-1 release without modifying that of MMP-9, leading to a decrease in the MMP-9 to TIMP-1 ratio
Parker et al., Cytokines Cell Mol Ther 2000 (Mast-Cell Sarcoma) : In summary, our data suggest that, in a mouse model, antisense IL-10 has substantive effects in reducing IL-10 translation and inhibiting IL-10 mediated TIMP upregulation, and, by doing so, allows IL-10 transfected mastocytoma to grow unchecked
Guedez et al., Blood 2001 (Lymphoma, Non-Hodgkin) : Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis ... IL-10 has been shown to up-regulate TIMP-1 in tissue macrophages, monocytes, and prostate cancer cell lines, but IL-10 modulation of TIMP-1 in B cells and the effect of TIMP-1 on IL-10 expression has not been previously studied ... It was found that TIMP-1 expression regulates IL-10 levels in B cells and that TIMP-1 mediates specific B-cell differentiation steps ... TIMP-1 inhibition of apoptosis is not IL-10 dependent ... Thus, TIMP-1 regulates IL-10 expression in B-cell NHL and, through the inhibition of apoptosis, appears responsible for the negative prognosis associated with IL-10 expression in these tumors
Wang et al., Cancer Biol Ther 2002 (Prostatic Neoplasms) : IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines ... Electrophoretic mobility shift assays ( EMSAs ) and enzyme linked immuno-sandwich assays ( ELISAs ) showed that IL-10 stimulated the rapid translocation of IL-10E1 to the nucleus and the activation of TIMP-1 expression in 4 different androgen dependent primary prostate tumor lines generated in our laboratory ( i.e. HPCA-5a, 5b, 5c and 5d lines )
Stearns et al., Mol Cancer Res 2003 (Prostatic Neoplasms) : IL-10E1 signaling normally induced the expression of tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) and LLnL treatment of the HPCA-10a and HPCA-10c cells significantly enhanced IL-10 induction of TIMP-1 levels to block tumor cell invasion in modified Boyden chamber invasion assays
Zhang et al., World J Gastroenterol 2004 (Liver Cirrhosis) : Effect of interleukin-10 and platelet derived growth factor on expressions of matrix metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 in rat fibrotic liver and cultured hepatic stellate cells
Holven et al., Stroke 2006 (Atherosclerosis...) : Our main findings were : ( 1 ) hyperhomocysteinemic subjects had raised serum levels of MMP-9 and MMP-9/TIMP-1 ratio comparing healthy controls ; ( 2 ) although IL-10 markedly suppressed MMP-9 release from PBMCs in controls, no or only minor effect was seen in hyperhomocysteinemic subjects ; ( 3 ) although IL-10 enhanced TIMP-1 levels in PBMCs from both hyperhomocysteinemic and control subjects, the increase was more prominent in controls, resulting in a marked difference in IL-10 induced changes in MMP-9/TIMP-1 ratio between these 2 groups ; and ( 4 ) comparing PBMCs from controls, cells from hyperhomocysteinemic individuals had impaired IL-10 induced STAT3 phosphorylation
Hu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008 (Myocardial Infarction...) : In vivo myocardial IL-10 transfer reduced myocardial MMP and collagen expression and increasing the TIMP expression
Stearns et al., Oncol Res 1995 (Prostatic Neoplasms) : In situ hybridization assays with TIMP-1 oligonucleotide antisense probes confirmed the northern blot results and indicated that IL-10 preferentially stimulated TIMP-1 mRNA synthesis
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments