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EPHB2 — PTEN
Text-mined interactions from Literome
Mosser et al., Biochem Biophys Res Commun 2001
(MAP Kinase Signaling System) :
In Cos-7 cells, overexpression of wild-type
PTEN had no effect on
ERK2 phosphorylation in response to acute insulin stimulation
Huang et al., Arterioscler Thromb Vasc Biol 2002
:
PTEN was expressed endogenously in VSMCs, and PTEN overexpression
inhibited PDGF induced phosphorylation of p70 ( s6k ), Akt, and glycogen synthase kinase-3-alpha and -beta but not
ERK1 or -2
Zhang et al., Chin J Cancer 2002
(Endometrial Neoplasms) :
[ Role of suppressor encoprotein
PTEN in IGF-1
induced activation of
ERK in endometrial carcinoma cells ] ... The objective of this paper was to study extracellular signal regulated kinase ( ERK ) activation in endometrial carcinoma cell line Ishikawa under the stimulation of IGF-1, and to elucidate the
role of suppressor encoprotein
phosphatase and tensin homologue(PTEN) in activation of
ERK ... The activation of
ERK2 was
inhibited obviously by
PTEN at 30 min, 2 h, and 24 h ... The activation of
ERK2 was
inhibited obviously by
PTEN , not by PTEN ( G129E )
Zhang et al., Chin Med J (Engl) 2003
(Endometrial Neoplasms) :
The activation of
ERK2 was
inhibited markedly by
PTEN , but not by PTEN ( G129E )
Kanda et al., J Cancer Res Clin Oncol 2009
(Prostatic Neoplasms...) :
Stable
PTEN expression in PTEN-null UM-UC-3 cells
increased serum induced
ERK activation and sensitivity to PD98059-treatment, and reduced sensitivity to LY294002 after 6 weeks of exposure
Takashima et al., J Gastroenterol 2009
:
Expression of
WT-PTEN also
caused decreased activation of Akt, p70 ( S6K ), and
Erk signaling pathways
Thomas et al., Neuro Oncol 2010
(Brain Neoplasms...) :
PTEN augments SPARC suppression of proliferation and inhibits SPARC induced migration by
suppressing SHC-RAF-ERK and AKT signaling
Chetram et al., Mol Cancer Res 2011
(Prostatic Neoplasms) :
By Western blot analysis, we observed that
PTEN inhibited basal AKT phosphorylation but not
ERK1/2 phosphorylation in PTEN expressing cells ... Upon CXCR4 stimulation,
PTEN inhibited
ERK1/2 phosphorylation but not phosphorylation of AKT
Chetram et al., J Recept Signal Transduct Res 2012
(MAP Kinase Signaling System...) :
PTEN regulation of
ERK1/2 signaling in cancer ... However, the detailed mechanism by which
PTEN regulates
ERK1/2 is poorly understood ... In this review, we discuss the
role of
PTEN in regulating
ERK1/2 by directly targeting shc/Raf/MEK and PI3K/AKT cascades, and a putative cross-talk between the two
Gupta et al., Mol Biol Cell 2012
(Alzheimer Disease...) :
Results suggest that
PTEN acting through FAK, the direct protein substrate of PTEN,
prevents ERK activation