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WNT3 — WNT5A
Text-mined interactions from Literome
Mikels et al., PLoS Biol 2006
:
We find that purified
Wnt5a inhibits Wnt3a protein induced canonical
Wnt signaling in a dose dependent manner, not by influencing beta-catenin levels but by downregulating beta-catenin induced reporter gene expression
Masckauchán et al., Mol Biol Cell 2006
:
Wnt5a induced noncanonical
Wnt signaling in endothelial cells, as measured by Dishevelled and ERK1/2 phosphorylation, and inhibition of canonical Wnt signaling, a known property of Wnt5a ... Thus,
Wnt5a acts through noncanonical
Wnt signaling to promote angiogenesis
Katoh et al., Int J Mol Med 2007
(Arthritis, Rheumatoid...) :
LIF induced
Wnt5a activates canonical
Wnt signaling in mouse embryonic stem cells for self-renewal ... STAT3 induced
Wnt5a activates non-canonical
Wnt signaling in rat cardiac myocytes for N-cadherin dependent aggregation ...
WNT5A then
activates canonical
WNT signaling in epithelial cells ... IL6 induced
WNT5A activates canonical
WNT signaling for autocrine proliferation of human synovial fibroblasts in rheumatoid arthritis ... Oncogenic
WNT5A activates canonical
WNT signaling in cancer stem cells for self-renewal, and non-canonical WNT signaling at the tumor-stromal interface for invasion and metastasis
MacLeod et al., Am J Physiol Gastrointest Liver Physiol 2007
(Adenocarcinoma...) :
Wnt5a secretion stimulated by the extracellular calcium sensing receptor
inhibits defective
Wnt signaling in colon cancer cells ... Our findings demonstrate that APC status plays a key role as a determinant of Wnt5a secretion and suggest that CaSR mediated secretion of
Wnt5a will
inhibit defective
Wnt signaling in APC truncated cells in an autocrine manner
Nemeth et al., Proc Natl Acad Sci U S A 2007
:
Wnt5a inhibits canonical
Wnt signaling in hematopoietic stem cells and enhances repopulation
Andersson et al., PloS one 2008
:
In summary, we hereby describe a
Wnt5a regulation of
Wnt/PCP signaling in the DA lineage and provide evidence for multiple functions of Wnt5a in the VM in vivo, including the regulation of VM morphogenesis, DA progenitor cell division, and differentiation of NR4A2+ DA precursors
Roarty et al., Breast Cancer Res 2009
(Mammary Neoplasms, Experimental) :
Loss of TGF-beta or Wnt5a signalling resulted in stabilisation of nuclear beta-catenin and expression of Wnt/beta-catenin target genes suggesting that TGF-beta and
Wnt5a act to
inhibit Wnt/beta-catenin signalling in mammary epithelium ... The key findings here are that : TGF-beta and
Wnt5a regulate
Wnt/beta-catenin activity ; and loss of TGF-beta and Wnt5a redirect the phenotype of tumours so that they resemble tumours induced by activation of Wnt/beta-catenin
Huang et al., Pulm Pharmacol Ther 2009
:
Expression of
Wnt-5a protein significantly stimulated cell proliferation, and transfection with siRNA plasmids
suppressed Wnt-5 expression and cell proliferation
Mikels et al., J Biol Chem 2009
:
Emerging evidence suggests that
Wnt5a can
inhibit Wnt/beta-catenin signaling through interaction with the receptor Ror2
Huang et al., Oncol Rep 2010
(Carcinoma, Non-Small-Cell Lung...) :
Expression of
Wnt-5a protein significantly stimulated cell proliferation and transfection with siRNA plasmids
suppressed Wnt-5 expression and cell proliferation
Chen et al., Mol Cell Proteomics 2011
:
Furthermore,
Wnt-5a expression
suppressed canonical
Wnt signaling induced by Wnt-3a
Li et al., Cancer Biol Ther 2010
(Esophageal Neoplasms) :
The epigenetic disruption of
WNT5A would thus
contribute directly to the aberrant activation of
WNT/ß-catenin signaling during ESCC pathogenesis
van Amerongen et al., Dev Biol 2012
(Wnt Signaling Pathway) :
Wnt5a can both activate and
repress Wnt/ß-catenin signaling during mouse embryonic development
Kwack et al., Exp Dermatol 2013
:
Wnt5a attenuates
Wnt/ß-catenin signalling in human dermal papilla cells ... Here, we investigated the question of whether
Wnt5a can
affect canonical
Wnt/ß-catenin signalling in DP cells
Nishita et al., Clinical calcium 2013
(Wnt Signaling Pathway) :
In this article, we will overview the molecular basis of non-canonical Wnt signaling, with a particular emphasis on the roles of non-canonical
Wnt signaling
mediated by
Wnt5a and its cognate receptors, Ror-family of receptor tyrosine kinases ( Ror1, Ror2 ), and will introduce up-to-date information on non-canonical Wnt signaling obtained from recent studies about pathological conditions, including cancer progression and chronic inflammation