Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — NOS3

Text-mined interactions from Literome

Chan et al., Infect Immun 2001 : Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK , MKK7-JNK, and NF-kappaB signaling pathways
Ying et al., FASEB J 2002 (MAP Kinase Signaling System) : PD-098059, a MEK1 inhibitor, and SB-203580, an inhibitor of p38 MAPKalpha-gamma, diminished NOS3 expression and production of TGF-beta1 and NOx
Fisslthaler et al., Nitric Oxide 2003 : The MEK1 inhibitor, PD 98059, also enhanced eNOS expression in native and cultured endothelial cells, an effect which was independent of ERK1/2 and associated with an increase in the DNA binding activity of AP-1 and Sp1