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IRS1 — RELA

Text-mined interactions from Literome

Kuo et al., Oncogene 2007 : We conclude that the recruitment of IRS-1 to activated ALK and the activation of NF-kappaB are essential for the autocrine growth and survival signaling of MK
Nishiumi et al., Toxicological sciences : an official journal of the Society of Toxicology 2010 (Insulin Resistance) : TCDD also stimulated the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and c-Jun N-terminal kinase (JNK), and their inhibitors abrogated the TCDD induced downregulation of IRbeta, IRS1 , and GLUT4 ; upregulation of TNF-alpha ; and activation of NF-kappaB
Jain et al., Mol Nutr Food Res 2010 (Diabetes Mellitus, Type 2...) : While CDN and CP had no effect, activation of NFkappaB , Akt and glucose transporter-2 levels were decreased, insulin receptor substrate 1 (IRS-1) activation increased in livers of CDNC-rats ... CDNC is a potent hypoglycemic compound with anti-inflammatory activity apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB , Akt, and Glut-2 and increased IRS-1 activation in livers of type 2 diabetic rats