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MAPK8 — SIRT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK8 — SIRT1 (direct interaction, enzymatic study) Nasrin et al., PloS one 2009*
• IRef Biogrid Interaction: MAPK8 — SIRT1 (physical association, affinity chromatography technology) Nasrin et al., PloS one 2009*

Text-mined interactions from Literome

Ota et al., Oncogene 2006 (Breast Neoplasms...) : Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
Seo et al., Neurobiol Aging 2012 : SIRT1 activation also inhibited PrP ( 106-126 ) -mediated p38 mitogen activating protein kinase ( MAPK ) activation and caspase-3 cleavage, and increased the expression of anti-apoptotic Bcl-xL protein
Gao et al., J Biol Chem 2011 (Fatty Liver...) : Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 ( JNK1 ) activation contributes to hepatic steatosis in obesity
Park et al., J Periodontal Res 2013 : Resveratrol and Ad-SIRT1 decreased LPS and nicotine induced cytotoxicity, ROS and PGE2 production, and expression of cyclooxygenase-2 in HGFs. Resveratrol and Ad-SIRT1 inhibited nicotine and LPS mediated protein kinase C ( PKC ), phosphatidylinositol 3-kinase (PI3K), p38, ERK, JNK, MAPK and nuclear factor-kappa B ( NF-?B ) activation