◀ Back to MMP9
CAPN5 — MMP9
Text-mined interactions from Literome
Moshal et al., Am J Physiol Heart Circ Physiol 2006
(Hyperhomocysteinemia) :
Homocysteine mediated activation and mitochondrial translocation of
calpain regulates
MMP-9 in MVEC ... Our observations suggested that
calpain regulates Hcy induced
MMP-9 expression and activity ... Furthermore, studies with pharmacological inhibitors of calpain ( calpeptin and calpain-1 inhibitor ), ERK ( PD-98059 ) and the mitochondrial uncoupler FCCP suggested that
calpain and ERK-1/2 are the major events within the Hcy/MMP-9 signal axis and that intramitochondrial oxidative stress
regulates MMP-9 via ERK-1/2 signal cascade ... Taken together, these findings determine the novel
role of mitochondrial translocation of
calpain-1 in
MMP-9 activation during HHcy, in part, by increasing mitochondrial oxidative stress
Li et al., Diabetes 2011
(Cardiomyopathy, Hypertrophic...) :
In cultured cardiac fibroblasts, high glucose induced proliferation and
MMP activities were
prevented by
calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012
(Aortic Aneurysm, Abdominal...) :
Inhibition of
calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin,
attenuates AngII induced leukocyte infiltration, perivascular inflammation, and
MMP activation in mice
Singh et al., Can J Physiol Pharmacol 2012
(Anoxia...) :
On the other hand, inhibition of
calpain activity upon treatment with leupeptin or MDL 28170 significantly
reduced the
MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity