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EDN3 — MMP9

Text-mined interactions from Literome

Spinella et al., Cancer Res 2007 (Melanoma...) : ETs also increase HIF-1alpha expression under both normoxic and hypoxic conditions and its silencing by siRNA desensitizes COX-2 transcriptional activity, PGE ( 2 ) and VEGF production, and MMP activation in response to ET-3 , implicating, for the first time, HIF-1alpha/COX as downstream targets of ET ( B ) R signaling leading to invasiveness
Cheng et al., Acta Pharmacol Sin 2009 (Hypertrophy) : We hypothesized that dispersed NADPH oxidase, protein kinase Cepsilon ( PKCepsilon ), early response gene (ERG), and matrix metalloproteinase 9(MMP-9) across the heart by isoproterenol ( ISO ) medication might be mediated by the endothelin ( ET ) - ROS pathway