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HRG — MMP9

Text-mined interactions from Literome

Tang et al., J Nutr Biochem 2008 (Breast Neoplasms...) : Resveratrol significantly inhibited HRG-beta1 mediated MMP-9 expression in human breast cancer cells ... MEK inhibitor induced a marked reduction in MMP-9 expression, and it suggested that ERK1/2 cascade could play an important role in HRG-beta1 mediated MMP-9 expression
Pan et al., Evidence-based complementary and alternative medicine : eCAM 2011 : In parallel, pterostilbene also inhibited protein and mRNA expression of MMP-9 driven by HRG-ß1, suggesting that pterostilbene decreased HRG-ß1 mediated MMP-9 induction via transcriptional regulation
Kim et al., Exp Mol Med 2012 (Breast Neoplasms...) : Herein we examined the regulation mechanism of heregulin- ß1 (HRG) induced MMP-1 and -9 expression in breast cancer cell lines ... In addition, HRG induced MMP-1 and -9 expression was significantly decreased by MEK1/2 inhibitor, U0126 but not by phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294002 ... To confirm the role of MEK/ERK pathway on HRG induced MMP-1 and -9 expression, MCF7 cells were transfected with constitutively active adenoviral- MEK ( CA-MEK ) ... HRG induced MMP-1 and -9 expressions were significantly decreased by lapatinib, which inhibits HER1 and HER2 activity, in both vector alone and HER2 overexpressed MCF7 cells ... Finally, HRG induced MMP-1 and MMP-9 expression was decreased by HER3 siRNA overexpression ... Taken together, we suggested that HRG induced MMP-1 and MMP-9 expression is mediated through HER3 dependent pathway and highly expressed HER2 may be associated with more aggressive metastasis than the low expressed HER2 in breast cancer cells
Asrani et al., Mol Cancer Res 2013 : We also report that Fn14 depleted, HER2 overexpressing MCF7 cells have reduced basal cell migration capacity and reduced HRG1-ß1 stimulated cell migration, invasion, and matrix metalloproteinase (MMP)-9 expression