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MMP9 — TNFSF10
Text-mined interactions from Literome
Zhou et al., Hepatobiliary Pancreat Dis Int 2008
(Pancreatic Neoplasms) :
The purpose of this study was to find out if
TRAIL could
induce the expression of uPA, IL-8,
MMP-7 and MMP-9.and to explore the corresponding potential signaling transduction pathway in pancreatic cancer cells ...
TRAIL can
stimulate the expression of uPA, IL-8,
MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt ... The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in
TRAIL induced expression of uPA, IL-8,
MMP-7 and MMP-9
Kim et al., Biochem Biophys Res Commun 2008
(Astrocytoma) :
TRAIL induces
MMP-9 expression via ERK activation in human astrocytoma cells ... We demonstrated that
TRAIL induces
MMP-9 expression in human astrocytoma cells, which is preceded by activation of extracellular signal regulated protein kinase ( ERK ) ... The specific MEK inhibitor, U0126, significantly blocks
TRAIL mediated NF-kappaB activation and subsequent
MMP-9 induction
Jin et al., Biomed Pharmacother 2013
(Carcinoma, Hepatocellular...) :
In addition, c-Jun/AP-1 was rapidly activated upon stimulation with anisomycin ; however, the knockdown of c-Jun/AP-1 expression by c-Jun siRNA markedly reduced anisomycin plus
TRAIL induced loss of
MMP and apoptosis