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CSE — NOS3

Text-mined interactions from Literome

Cui et al., Am J Respir Cell Mol Biol 2005 : In this study, we evaluated the role of calpain-calpastatin in CSE induced decrease in eNOS gene expression ... To investigate whether CSE induced inhibition of eNOS gene expression is caused by decreased calpain activity due to an increase in calpastatin protein content, we cloned calpastatin gene from PAEC and constructed adenovirus vectors containing calpastatin ... Incubation of PAEC with an antisense oligodeoxyribonucleotide of calpastatin prevented CSE induced increases in calpastatin protein and CSE induced decreases in calpain activity, eNOS gene transcription, activity and protein content of eNOS, and NO release ... These results indicate that CSE induced inhibition of eNOS expression in PAEC is caused by calpain inhibition due to an increase in calpastatin protein content
Michaud et al., J Mol Cell Cardiol 2006 (Cardiovascular Diseases) : We found that CSE inhibited Akt/eNOS phosphorylation and NO release in VEGF stimulated HUVECs