Kumada et al., Circulation 2004
(Arteriosclerosis...) :
Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages ... Adiponectin significantly increased interleukin-10 (IL-10) mRNA expression at the transcriptional level within 6 hours and significantly increased IL-10 protein secretion within 24 hours ... Adiponectin selectively increased TIMP-1 expression in human monocyte derived macrophages through IL-10 induction
Manigrasso et al., J Clin Endocrinol Metab 2005
(Obesity...) :
Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages
Matsumoto et al., World J Gastroenterol 2006
:
Adiponectin supresses TNF-alpha production and induces IL-10 production by Kupffer cells in response to LPS stimulation, and a lack of adiponectin enhances LPS induced liver injury