Gene interactions and pathways from curated databases and text-mining

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IL12A — TYK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sudarshan et al., J Immunol 1999 : We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2, TYK2 , and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
Shimoda et al., Blood 2002 : Tyk2 is activated in response to interleukin-12 (IL-12) and is essential for IL-12 induced T-cell function, including interferon-gamma (IFN-gamma) production and Th1 cell differentiation
Natarajan et al., J Immunol 2002 (Demyelinating Diseases...) : In vitro treatment of activated T cells with curcumin inhibited IL-12 induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2 , and STAT3 and STAT4 transcription factors
Sugimoto et al., Eur J Immunol 2003 : IL-12 activates TYK2 and Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription ( STAT ) proteins
Schleicher et al., Eur J Immunol 2004 (Leishmaniasis, Cutaneous) : Thus, Tyk2 is required for the IL-12 response of NK cells and CD8 ( + ) T cells in L. major infected mice, but not for the generation of Th1 cells and the ultimate control of the disease
Muthian et al., J Clin Immunol 2004 (Disease Models, Animal...) : In vitro treatment of activated T cells with quercetin blocks IL-12 induced tyrosine phosphorylation of JAK2, TYK2 , STAT3, and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Muthian et al., J Neurosci Res 2006 (Disease Models, Animal...) : Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the IL-12 induced tyrosine phosphorylation of JAK2, TYK2 , STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro
Tokumasa et al., Blood 2007 : Expression of Tyk2 in dendritic cells is required for IL-12 , IL-23, and IFN-gamma production and the induction of Th1 cell differentiation
Oyamada et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : Tyrosine kinase 2 (Tyk2) , a member of the JAK family, is involved in IL-12- and IL-23 mediated signaling
Conzelmann et al., Biochem Pharmacol 2010 : JAK2 mediated enhancing effects on IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system
Bacon et al., J Exp Med 1995 : Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 ... IL-12 , but not IL-2, stimulates the tyrosine phosphorylation of TYK2 and JAK2, whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Yu et al., J Immunol 1996 : Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells