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EPHB2 — TLR4

Text-mined interactions from Literome

An et al., Immunology 2002 : Involvement of ERK , p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK, ERK 1/2, p38, and JNK/SAPK
Goral et al., J Immunol 2005 (Inflammation) : Acute ethanol treatment inhibited IL-6 and TNF-alpha synthesis and impaired p38 and ERK1/2 activation induced by TLR2, TLR4 , and TLR9 ligands
Miller et al., Arterioscler Thromb Vasc Biol 2005 (Atherosclerosis) : In turn, TLR4 regulated phosphorylation of ERK1/2 but not of Akt, suggesting that mmLDL induced PI3K activation is TLR4 independent
Aki et al., Genes Cells 2005 : Furthermore, overall cellular tyrosine phosphorylation and TLR4 mediated activation of IkappaB-alpha, Erk and p38 but not of JNK, were also down-regulated in Csk knockdown cells
Banerjee et al., Proc Natl Acad Sci U S A 2006 : Despite rescuing TLR dependent ERK activation in nfkb1 ( -/- ) bone marrow derived macrophages by using an estrogen receptor regulated version of the mitogen activated protein 3 kinase, c-Raf ( Raf : ER ), CpG or LPS induction of IL-10 was only partially restored in nfkb1 ( -/- ) cells expressing Raf : ER, a finding consistent with NF-kappaB1 regulating IL-10 by a combination of ERK independent and -dependent mechanisms
Hayashi et al., Journal of thrombosis and haemostasis : JTH 2006 : Lipopolysaccharide induced decreased protein S expression in liver cells is mediated by MEK/ERK signaling and NFkappaB activation : involvement of membrane bound CD14 and toll-like receptor-4
Dubourdeau et al., J Immunol 2006 (MAP Kinase Signaling System) : Our investigations revealed that immunocompetent TLR2, TLR4 , and MyD88 knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs ERK and p38 was not affected in TLR2, TLR4, or MyD88 knockout mice following stimulation with conidia
Pathak et al., J Immunol 2006 : TLR4/PI3K dependent ERK1/2 and p38 MAPK signaling converged upon activation of mitogen- and stress activated protein kinase 1 ( MSK1 )
Ha et al., J Immunol 2007 : In this study, we show that pneumolysin is required for up-regulation of MUC5AC mucin via TLR4 dependent activation of ERK in human epithelial cells in vitro and in mice in vivo
Toshchakov et al., J Immunol 2007 (MAP Kinase Signaling System) : TLR4- and TLR2-BBPs also strongly inhibited LPS induced activation of ERK
Kawakami et al., J Rheumatol 2007 (Sjogren's Syndrome) : TLR ligands induced phosphorylation of ERK , JNK, and p38 in HSG cells, but not Akt phosphorylation or activation of NF-kappaB p65
Loniewski et al., Mol Immunol 2007 : ERK activation in macrophages by TLR4 and -7 is mediated via a MAP3K, called TPL2/COT, which under unstimulated conditions is associated with NF kappa B1 p105, a member of the I kappa B family of proteins ... In contrast to TLR4 signaling, TLR7 activation of ERK , JNK pathways and phosphorylation of p105 and I kappa B alpha are completely inhibited in TRAF6 knockdown cells ... These results suggest that while TRAF6 is absolutely essential for TLR7 activation of ERK, JNK and NF kappa B pathways, TLR4 induced ERK , JNK pathways and IKK mediated phosphorylation of I kappa B family members as well as cytokine expression are differentially sensitive to the cellular levels of TRAF6
Pace et al., Immunology 2008 : The LPS increased the expression of TLR4 and induced both NF-kappaB and ERK1/2 activation
West et al., Immunology 2008 (Vasculitis) : ISO-1 is a promising parent molecule which inhibits TLR induced ERK activation and inflammatory cytokine production in monocytes, whose role may be complicated by cell-type specificity
Lee et al., Int Immunopharmacol 2010 (Dermatitis) : Hirsutenone, ERK inhibitor or Bay 11-7085 also prevented the lipopolysaccharide induced expression of Toll-like receptor 4 , the phosphorylation of inhibitory kappaB-alpha, the activation of NF-kappaB and the expression of ERK
He et al., J Cell Biochem 2010 : The activation of TLR4 by LPS modulated the expression of TLRs, induced the phosphorylation of NF-kappaB, P38, and ERK42/44 , and up-regulated the gene expression of cytokines IL-8, IFN-alpha, IFN-beta, and TNF-alpha, suggesting EPCs expressed functional TLR4
Park et al., Oncogene 2011 (Adenocarcinoma...) : Together, these findings suggest that the new cancer associated ligand, PAUF, may activate TLR mediated ERK signaling to produce the protumorigenic cytokines, but inhibits TLR mediated NF-?B signaling, thereby facilitating tumor growth and escape from innate immune surveillance
Hayashi et al., Gastroenterology research and practice 2010 : These data suggest that the LPS induced decrease in PS expression in hepatocytes and SECs and LPS induced decrease in C4BP expression in hepatocytes are mediated by MEK/ERK signaling and NF?B activation and that membrane bound CD14 and TLR-4 are involved in this mechanism
Ta et al., Atherosclerosis 2010 : DPP-4 ( CD26 ) inhibitor alogliptin inhibits TLR4 mediated ERK activation and ERK dependent MMP-1 expression by U937 histiocytes ... Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and ERK dependent MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Watts et al., Am J Physiol Cell Physiol 2011 (MAP Kinase Signaling System...) : Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88 dependent ERK activation in medullary thick ascending limb
Küper et al., American journal of physiology. Renal physiology 2012 : In conclusion, these results propose that LPS mediates enhanced COX-2 expression in IMCD cells by 1 ) TLR4 mediated activation of the NF-?B signaling pathway, 2 ) TLR4 dependent release of TGF-a with subsequent activation of the EGFR and downstream MAPKs p38 and ERK1/2 , and 3 ) TLR4 mediated, EGFR independent activation of JNK that negatively regulates NF-?B activation
Rabadi et al., American journal of physiology. Renal physiology 2012 (MAP Kinase Signaling System) : In summary, UA after IRI mediates the acetylation and release of HMGB1 from endothelial cells by mechanisms that involve calcium mobilization, the MEK/Erk pathway, and activation of TLR4
Brewster et al., J Surg Res 2012 (Anoxia...) : TLR4 did not affect phosphorylated ERK levels
Wu et al., Food Chem Toxicol 2012 (Melanoma) : Our flow cytometry and Western blot data showed that paclitaxel activated TLR4-MyD88-ERK signaling and that IS treatment could effectively inhibit this paclitaxel induced activation of TLR4-MyD88-ERK signaling
Zhang et al., PloS one 2013 (MAP Kinase Signaling System) : YCP interaction with TLR2 and TLR4 led to the activation of intracellular p38, ERK and JNK, as well as the translocation of transcriptional factor NF-?B into nucleus
Wang et al., Dig Dis Sci 2013 (Carcinoma, Hepatocellular...) : LPS-TLR4 induced activation of ERK and JNK signaling promotes cell proliferation through regulating Bax translocation to mitochondria